Targeted deletion of HIF-1alpha gene in T cells prevents their inhibition in hypoxic inflamed tissues and improves septic mice survival.

Targeted deletion of HIF-1alpha gene in T cells prevents their inhibition in hypoxic inflamed tissues and improves septic mice survival.

<h4>Background</h4>Sepsis patients may die either from an overwhelming systemic immune response and/or from an immunoparalysis-associated lack of anti-bacterial immune defence. We hypothesized that bacterial superantigen-activated T cells may be prevented from contribution into anti-bact...

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Main Authors: Manfred Thiel, Charles C Caldwell, Simone Kreth, Satoshi Kuboki, P Chen, Patrick Smith, Akio Ohta, Alex B Lentsch, Dmitry Lukashev, Michail V Sitkovsky
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-09-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0000853&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0000853&type=printable

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