Hydrogen Sulfide (H<sub>2</sub>S) Mitigates Sepsis-Induced Adrenal Dysfunction via Inhibition of TNFα-Mediated Necroptosis

Hydrogen Sulfide (H<sub>2</sub>S) Mitigates Sepsis-Induced Adrenal Dysfunction via Inhibition of TNFα-Mediated Necroptosis

Background: Sepsis is a life-threatening condition that is characterized by systemic inflammation and organ dysfunction, with adrenal dysfunction being a significant complication. This study aimed to investigate the role of necroptosis and hydrogen sulfide (H<sub>2</sub>S) in sepsis-indu...

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Main Authors: Kai Ma, Jingwen Huang, Jin Zhang, Yuan Tian, Jing Hu, Linhao Ma, Changnan Wang
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Pathogens
Subjects:
sepsis
adrenal dysfunction
necroptosis
gene knockout mice
hydrogen sulfide
TNFα
Online Access:https://www.mdpi.com/2076-0817/14/5/439
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