ASIC3: A Lactic Acid Sensor for Cardiac Pain
Angina, the prototypic vasoocclusive pain, is a radiating chest pain that occurs when heart muscle gets insufficient blood because of coronary artery disease. Other examples of vasoocclusive pain include the acute pain of heart attack and the intermittent pains that accompany sickle cell anemia and...
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| Format: | Article |
| Language: | English |
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Wiley
2001-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2001.254 |
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| _version_ | 1832547470807138304 |
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| author | D.C. Immke E.W. McCleskey |
| author_facet | D.C. Immke E.W. McCleskey |
| author_sort | D.C. Immke |
| collection | DOAJ |
| description | Angina, the prototypic vasoocclusive pain, is a radiating chest pain that occurs when heart muscle gets insufficient blood because of coronary artery disease. Other examples of vasoocclusive pain include the acute pain of heart attack and the intermittent pains that accompany sickle cell anemia and peripheral artery disease. All these conditions cause ischemia � insufficient oxygen delivery for local metabolic demand — and this releases lactic acid as cells switch to anaerobic metabolism. Recent discoveries demonstrate that sensory neurons innervating the heart are richly endowed with an ion channel that is opened by, and perfectly tuned for, the lactic acid released by muscle ischemia[1,2]. |
| format | Article |
| id | doaj-art-e6c1ffc3d269414883782865a30ae9bf |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2001-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-e6c1ffc3d269414883782865a30ae9bf2025-02-03T06:44:38ZengWileyThe Scientific World Journal1537-744X2001-01-01151051210.1100/tsw.2001.254ASIC3: A Lactic Acid Sensor for Cardiac PainD.C. Immke0E.W. McCleskey1Vollum Institute, Oregon Health & Science University, Portland, OR 97201-3098, USAVollum Institute, Oregon Health & Science University, Portland, OR 97201-3098, USAAngina, the prototypic vasoocclusive pain, is a radiating chest pain that occurs when heart muscle gets insufficient blood because of coronary artery disease. Other examples of vasoocclusive pain include the acute pain of heart attack and the intermittent pains that accompany sickle cell anemia and peripheral artery disease. All these conditions cause ischemia � insufficient oxygen delivery for local metabolic demand — and this releases lactic acid as cells switch to anaerobic metabolism. Recent discoveries demonstrate that sensory neurons innervating the heart are richly endowed with an ion channel that is opened by, and perfectly tuned for, the lactic acid released by muscle ischemia[1,2].http://dx.doi.org/10.1100/tsw.2001.254 |
| spellingShingle | D.C. Immke E.W. McCleskey ASIC3: A Lactic Acid Sensor for Cardiac Pain The Scientific World Journal |
| title | ASIC3: A Lactic Acid Sensor for Cardiac Pain |
| title_full | ASIC3: A Lactic Acid Sensor for Cardiac Pain |
| title_fullStr | ASIC3: A Lactic Acid Sensor for Cardiac Pain |
| title_full_unstemmed | ASIC3: A Lactic Acid Sensor for Cardiac Pain |
| title_short | ASIC3: A Lactic Acid Sensor for Cardiac Pain |
| title_sort | asic3 a lactic acid sensor for cardiac pain |
| url | http://dx.doi.org/10.1100/tsw.2001.254 |
| work_keys_str_mv | AT dcimmke asic3alacticacidsensorforcardiacpain AT ewmccleskey asic3alacticacidsensorforcardiacpain |