An Overview of Live Attenuated Recombinant Pseudorabies Viruses for Use as Novel Vaccines
Pseudorabies virus (PRV) is a double-stranded, DNA-based swine virus with a genome approximating 150 kb in size. PRV has many nonessential genes which can be replaced with genes encoding heterologous antigens but without deleterious effects on virus propagation. Recombinant PRVs expressing both nati...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2014/824630 |
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| _version_ | 1832565750953410560 |
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| author | Bo Dong Dante S. Zarlenga Xiaofeng Ren |
| author_facet | Bo Dong Dante S. Zarlenga Xiaofeng Ren |
| author_sort | Bo Dong |
| collection | DOAJ |
| description | Pseudorabies virus (PRV) is a double-stranded, DNA-based swine virus with a genome approximating 150 kb in size. PRV has many nonessential genes which can be replaced with genes encoding heterologous antigens but without deleterious effects on virus propagation. Recombinant PRVs expressing both native and foreign antigens are able to stimulate immune responses. In this paper, we review the current status of live attenuated recombinant PRVs and live PRV-based vector vaccines with potential for controlling viral infections in animals. |
| format | Article |
| id | doaj-art-e6bbf90e852342baa94293753ef94830 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-e6bbf90e852342baa94293753ef948302025-02-03T01:06:54ZengWileyJournal of Immunology Research2314-88612314-71562014-01-01201410.1155/2014/824630824630An Overview of Live Attenuated Recombinant Pseudorabies Viruses for Use as Novel VaccinesBo Dong0Dante S. Zarlenga1Xiaofeng Ren2Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northeast Agricultural University, 59 Mucai Street, Xiangfang District, Harbin 150030, ChinaAnimal Parasitic Diseases Laboratory, Agricultural Research Service, Beltsville, MD 20705, USADepartment of Preventive Veterinary Medicine, College of Veterinary Medicine, Northeast Agricultural University, 59 Mucai Street, Xiangfang District, Harbin 150030, ChinaPseudorabies virus (PRV) is a double-stranded, DNA-based swine virus with a genome approximating 150 kb in size. PRV has many nonessential genes which can be replaced with genes encoding heterologous antigens but without deleterious effects on virus propagation. Recombinant PRVs expressing both native and foreign antigens are able to stimulate immune responses. In this paper, we review the current status of live attenuated recombinant PRVs and live PRV-based vector vaccines with potential for controlling viral infections in animals.http://dx.doi.org/10.1155/2014/824630 |
| spellingShingle | Bo Dong Dante S. Zarlenga Xiaofeng Ren An Overview of Live Attenuated Recombinant Pseudorabies Viruses for Use as Novel Vaccines Journal of Immunology Research |
| title | An Overview of Live Attenuated Recombinant Pseudorabies Viruses for Use as Novel Vaccines |
| title_full | An Overview of Live Attenuated Recombinant Pseudorabies Viruses for Use as Novel Vaccines |
| title_fullStr | An Overview of Live Attenuated Recombinant Pseudorabies Viruses for Use as Novel Vaccines |
| title_full_unstemmed | An Overview of Live Attenuated Recombinant Pseudorabies Viruses for Use as Novel Vaccines |
| title_short | An Overview of Live Attenuated Recombinant Pseudorabies Viruses for Use as Novel Vaccines |
| title_sort | overview of live attenuated recombinant pseudorabies viruses for use as novel vaccines |
| url | http://dx.doi.org/10.1155/2014/824630 |
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