Comprehensive single-cell analysis deciphered the immunoregulatory mechanism of TPPU in alleviating sepsis-related acute liver injury

Comprehensive single-cell analysis deciphered the immunoregulatory mechanism of TPPU in alleviating sepsis-related acute liver injury

Introduction: Sepsis-related acute liver injury involves complex immune dysfunctions. Epoxyeicosatrienoic acids (EETs), bioactive molecules derived from arachidonic acid (AA) via cytochrome P450 (CYP450) and rapidly hydrolyzed by soluble epoxide hydrolase (sEH), possess anti-inflammatory properties....

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Bibliographic Details
Main Authors: Juan Li, Mengjuan Xuan, Li Yang, Yingru Liu, Na Lou, Leiya Fu, Qingmiao Shi, Chen Xue
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Journal of Advanced Research
Subjects:
TPPU
Macrophages
Neutrophils
Sepsis-related acute liver injury
Cytochrome P450
Arachidonic acid metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S209012322500116X
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