Remimazolam Combined with Andrographolide Improve Postoperative Cognitive Dysfunction in Rats after Cardiopulmonary Bypass through the AMPK/SIRT1 Signaling Pathway

Remimazolam Combined with Andrographolide Improve Postoperative Cognitive Dysfunction in Rats after Cardiopulmonary Bypass through the AMPK/SIRT1 Signaling Pathway

Introduction: The effects of remimazolam (Re) in combination with andrographolide (AP) on learning, memory, and motor abilities in rats following cardiopulmonary bypass (CPB) surgery were studied. Methods: We hy...

Full description

Saved in:

Bibliographic Details
Main Authors:	Chong Chen, Lixia Lan, Kai Xu
Format:	Article
Language:	English
Published:	IMR Press 2025-01-01
Series:	Journal of Integrative Neuroscience
Subjects:	remimazolam andrographolide postoperative cognitive dys-function cardiopulmonary bypass ampk sirt1
Online Access:	https://www.imrpress.com/journal/JIN/24/1/10.31083/JIN25665
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Myocardial damage in cardioplegia and cardiopulmonary bypass
by: M.Т. Vatutin, et al.
Published: (2016-05-01)

Analysis of postoperative atrial fibrillation and its associated factors in Morrow procedures with cardiopulmonary bypass
by: Zhibin Hu, et al.
Published: (2025-01-01)

Cardiopulmonary bypass associated acute kidney injury: better understanding and better prevention
by: Xutao Yang, et al.
Published: (2024-12-01)

Unraveling the AMPK-SIRT1-FOXO Pathway: The In-Depth Analysis and Breakthrough Prospects of Oxidative Stress-Induced Diseases
by: Guangqi Guan, et al.
Published: (2025-01-01)

AlphaFold-based AI docking reveals AMPK/SIRT1-TFEB pathway modulation by traditional Chinese medicine in metabolic-associated fatty liver disease
by: Lulu Zhang, et al.
Published: (2025-02-01)

Utilization of cardiopulmonary bypass at radical nephrectomy for renal cell carcinoma with tumour thrombus
by: Chalairat Suk‐Ouichai, et al.
Published: (2025-01-01)

Comparing the safety and efficacy of remimazolam-based total intravenous anesthesia versus volatile agent-based anesthesia: a meta-analysis of randomized controlled trials
by: Ji-In Park, et al.
Published: (2025-02-01)

Perfusion mode as a factor of appearance of cognitive dysfunction in patients after on-pump coronary artery bypass grafting
by: S.M. Sudakevych, et al.
Published: (2018-11-01)

Prolonged Cardiopulmonary Bypass Time-Induced Endothelial Dysfunction via Glypican-1 Shedding, Inflammation, and Matrix Metalloproteinase 9 in Patients Undergoing Cardiac Surgery
by: Shiyi Li, et al.
Published: (2024-12-01)

Andrographolide prevents acute hyperammonemia-induced motor dysfunction in rats. Evidences for its mechanism of action
by: Arghya Mukherjee, et al.
Published: (2025-02-01)

Comparative Study of Remimazolam and Midazolam During Sedated Upper Gastrointestinal Endoscopy: A Propensity Score Matching Analysis
by: Ryoji Ichijima, et al.
Published: (2025-01-01)

The Number of Microbubbles Generated During Cardiopulmonary Bypass Can Be Estimated Using Machine Learning From Suction Flow Rate, Venous Reservoir Level, Perfusion Flow Rate, Hematocrit Level, and Blood Temperature
by: Satoshi Miyamoto, et al.
Published: (2024-01-01)

Andrographolide-encapsulated nanoliposomes with gum Arabic surface modification inhibits cervical cancer growth: In vitro and in silico approaches
by: Rahmalillah Khairiah, et al.
Published: (2025-03-01)

Procedural sedative effect of remimazolam in ICU patients on invasive mechanical ventilation: a randomised, prospective study
by: Youli Tian, et al.
Published: (2025-01-01)

Association between cardiopulmonary bypass duration and early major adverse cardiovascular events after surgical repair of supravalvular aortic stenosis
by: Simeng Zhang, et al.
Published: (2025-01-01)

Comparison of the safety of remimazolam and propofol during general anesthesia in elderly patients: systematic review and meta-analysis
by: Xianchun Liu, et al.
Published: (2025-02-01)

Acute pancreatitis after double cardiac valve replacement: a case report
by: Wafae El Amraoui, et al.
Published: (2024-11-01)

Delta Neutrophil Index in Coronary Artery Bypass Surgery: An Innovation in Postoperative Mortality Assessment
by: Bilgiç A, et al.
Published: (2025-02-01)

Predictive Value of Systemic Immune Inflammation Index for Postoperative Atrial Fibrillation in Patients Undergoing Isolated Coronary Artery Bypass Grafting
by: Murat Selçuk, et al.
Published: (2021-12-01)

Direct Axillary Artery Cannulation as Standard Perfusion Strategy in Minimally Invasive Coronary Artery Bypass Grafting
by: Christian Sellin, et al.
Published: (2025-01-01)

Andrographolide suppresses cervical cancer progression by targeting angiogenesis and inducing apoptosis in a CAM-PDX model
by: Wanwan Zou, et al.
Published: (2025-02-01)

The mystery of methylene blue and its role in managing post-cardiac surgery vasoplegic shock
by: Mohamed Elbayomi, et al.
Published: (2025-12-01)

Effects and trend of steroid dosage reduction during cardiac surgery: A three-year retrospective analysis at a tertiary medical center
by: Jeng-Wei Chen, et al.
Published: (2025-02-01)

Major Aortopulmonary Collateral Arteries and Their Effects on Perioperative Parameters and Mortality of Children with Tetralogy of Fallot: A Case-control Study
by: Mohammadreza Edraki, et al.
Published: (2024-12-01)

Multimodal low-opioid anesthesia as a factor in reducing the activation of the proinflammatory response in cardiac surgery
by: S.R. Maruniak, et al.
Published: (2019-12-01)

Comparison of intraoperative neurophysiological monitoring between propofol and remimazolam during total intravenous anesthesia in the cervical spine surgery: a prospective, double-blind, randomized controlled trial
by: Myoung Hwa Kim, et al.
Published: (2025-02-01)

Trimetazidine: Activating AMPK Signal to Ameliorate Coronary Microcirculation Dysfunction after Myocardial Infarction
by: Xiaolong Qu, et al.
Published: (2025-01-01)

Emerging roles of mitochondrial sirtuin SIRT5 in succinylation modification and cancer development
by: Zhangmin Ke, et al.
Published: (2025-01-01)

Prognostic impact of chronic obstructive pulmonary disease on short-term and long-term outcomes following coronary artery bypass grafting
by: Mohammad Sadeq Najafi, et al.
Published: (2025-01-01)

Ethanol extract of Polygonatum cyrtonema Hua mitigates non-alcoholic steatohepatitis in mice
by: Dongliang Chen, et al.
Published: (2025-01-01)

AMPK: An energy sensor for non-small cell lung cancer progression and treatment
by: Zhi-Ting Zhong, et al.
Published: (2025-02-01)

Does SIRT-1 Mediate Calorie Restriction and Prolong Life? – A Mini Review
by: Kordala Anna, et al.
Published: (2014-09-01)

Metformin ameliorates peripheral neuropathy in diabetic rats by downregulating autophagy via the AMPK pathway
by: Fangqin You, et al.
Published: (2025-01-01)

In situ simulation for cardiopulmonary resuscitation training: A systematic review
by: Andrea Cortegiani, et al.
Published: (2025-01-01)

Cerebral Microhemorrhages in Children With Congenital Heart Disease: Prevalence, Risk Factors, and Association With Neurodevelopmental Outcomes
by: Kristen N. Andersen, et al.
Published: (2025-02-01)

Kaempferol improves glucose uptake in skeletal muscle via an AMPK-dependent mechanism
by: William T. Moore, et al.
Published: (2023-11-01)

Maslinic acid improves mitochondrial function and inhibits oxidative stress and autophagy in human gastric smooth muscle cells
by: Zheng Xiaoying, et al.
Published: (2025-01-01)

SF1-specific deletion of the energy sensor AMPKγ2 induces obesity
by: Óscar Freire-Agulleiro, et al.
Published: (2025-02-01)

Role of sirtuin 1 (SIRT1) gene polymorphisms in pituitary adenoma development. Literature review
by: G. Morkūnaitė, et al.
Published: (2018-06-01)

Extracorporeal Cardiopulmonary Resuscitation—Where Do We Currently Stand?
by: Brandon E. Ferrell, et al.
Published: (2025-01-01)