Anticonvulsant Potential of Certain New (2E)-2-[1-Aryl-3-(1H-imidazol-1-yl)propylidene]-N-(aryl/H)hydrazinecarboxamides

Anticonvulsant Potential of Certain New (2E)-2-[1-Aryl-3-(1H-imidazol-1-yl)propylidene]-N-(aryl/H)hydrazinecarboxamides

Anticonvulsant potential and neurotoxicity of certain new imidazole-containing arylsemicarbazones 6a–p are reported. The test compounds 6a–p exhibited anticonvulsant activity mainly in the scPTZ screen. Compound 6p emerged as the most active surrogate displaying 100% protection at a dose level of 63...

Full description

Saved in:

Bibliographic Details
Main Authors:	Mohamed I. Attia, Mohamed N. Aboul-Enein, Aida A. El-Azzouny, Yousreya A. Maklad, Hazem A. Ghabbour
Format:	Article
Language:	English
Published:	Wiley 2014-01-01
Series:	The Scientific World Journal
Online Access:	http://dx.doi.org/10.1155/2014/357403
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Synthesis and X-Ray Crystal Structure of (1E)-1-(4-Chlorophenyl)-N-hydroxy-3-(1H-imidazol-1-yl)propan-1-imine
by: Mohamed I. Attia, et al.
Published: (2013-01-01)

Synthesis of N-[{5-Aryl-1,3,4-oxadiazole-2-yl}methyl]-4-methoxyaniline Derivatives and Their Anticonvulsant Activity
by: B. N. Prasanna Kumar, et al.
Published: (2013-01-01)

Palladium-Catalyzed C(sp3)-H Arylation of Benzo[b]thiophen-3(2H)-one 1,1-Dioxide
by: Hailong Liu, et al.
Published: (2019-01-01)

Syntheses and Antibacterial Studies of Some 1-Phenyl-3-(4-(2-ethanoloxy) phenyl)-5-aryl-1H-pyrazoles
by: Anju Goyal, et al.
Published: (2013-01-01)

Trifluoroacetic Acid as an Efficient Catalyst for the Room Temperature Synthesis of 2-Aryl-1-arylmethyl-1H-1,3-benzimidazoles in Aqueous Media
by: Mohammad R. Mohammadizadeh, et al.
Published: (2011-01-01)

Design, Synthesis, Antibacterial and Antifungal Activity of Novel 2-[(E)-2-aryl-1-ethenyl]-3-(2-sulfanyl-1H-benzo[d]imidazole-5-yl)-3,4- dihydro-4-quinolinones
by: Anisetti Ravinder Nath, et al.
Published: (2012-01-01)

Synthesis of Ruthenium Complex Based on 2,6-Bis(1-(phenyl)-1H-benzo[d]imidazol-2-yl)pyridine and 2-(1-Phenyl-1H-benzo[d]imidazol-2-yl)benzoate and Catalytical Oxidation Property of 1-(1H-Benzo[d]imidazol-2-yl)ethanol to 1-(1H-Benzo[d]imidazol-2-yl)ethanone with H2O2
by: Shenggui Liu, et al.
Published: (2017-01-01)

Theoretical Analysis of the Mechanism of the 1,3-Dipolar Cycloaddition of Benzodiazepine with N-Aryl-C-ethoxycarbonylnitrilimine
by: Khadija Nabih, et al.
Published: (2020-01-01)

Synthesis and Antimicrobial Activity of 1-[2-(10-p-Chlorobenzyl) phenothiazinyl]-3-(substituted aryl)-2-propen-1-ones
by: R. K. Upadhyay, et al.
Published: (2009-01-01)

Synthesis and Biological Activity of Some 3,4-Dihydro-4-(4-substituted aryl)-6-(naptho[2,1-b]furan-2-yl pyrimidine-2(1H)-one Derivatives
by: Sanjeevan S. Gaikwad, et al.
Published: (2012-01-01)

“On Water” Sonochemical Multicomponent Synthesis of Novel Bioactive 1,1′-(Aryl)bis(2-(cyclohexylamino)-2-oxoethane-1,1-diyl) Di(alkanoates and benzoates)
by: Manouchehr Mamaghani, et al.
Published: (2013-01-01)

The crystal structure of (E)-4-fluoro-N′-(1-(2-hydroxyphenyl)propylidene)benzohydrazide, C16H15FN2O2
by: Li Xiaohua, et al.
Published: (2023-08-01)

Aryl Hydrocarbon Receptor and Stem Cells
by: Thomas A. Gasiewicz, et al.
Published: (2017-01-01)

Synthesis and Antidepressant Activity of Some New 5-(1H-Indol-3-yl)-3-(substituted aryl)-4,5-dihydroisoxazoline Derivatives
by: Pravin O. Patil, et al.
Published: (2013-01-01)

Crystal structure of dibromido-(1-methyl-1H-imidazole-κ1N)-(3-(3-methyl-1H-imidazol-3-ium-1-yl)propanoato-κ1O)zinc(II), C11H16Br2N4O2Zn
by: Liu Pengju, et al.
Published: (2021-09-01)

Synthesis and Crystal Structure of 1-(4-Nitrobenzyl)-3-allyl-1H-benzo[d]imidazol-2(3H)-one
by: Dounia Belaziz, et al.
Published: (2013-01-01)

Synthesis and crystal structure analysis of 1-ethyl-1,3-dihydro-2H-benzo[d]imidazole-2-thione
by: Atash V. Gurbanov, et al.
Published: (2025-02-01)

Crystal structure of 1,2-bis(2,4-dinitro-1H-imidazol-1-yl)ethane – dimethylformamide (1/1), C11H13N9O9
by: Jun Yuan, et al.
Published: (2022-08-01)

Antioxidant Functions of the Aryl Hydrocarbon Receptor
by: Cornelia Dietrich
Published: (2016-01-01)

Novel Aryl Ether Derivatives as Antiinflammatory and Analgesics
by: P. Rashmi, et al.
Published: (2011-01-01)

A Facile Synthesis of Pyrido[2′,3′:3,4]pyrazolo[1,5-a]pyrimidine and Pyrido[2′,3′:3,4]pyrazolo[5,1-c][1,2,4]triazine Bearing a Thiophene Moiety
by: Tilal Elsaman, et al.
Published: (2013-01-01)

ynthesis and Characterization of 1-Aryl-5-hepta-O-acetyl-β-D-maltosyl-2-S-benzyl-2,4-isodithiobiurets
by: R. D. Ghuge, et al.
Published: (2012-01-01)

Synthesis and Antifungal Activities of 5-(o-Hydroxy phenyl)-2-[4'aryl-3'chloro-2'azetidinon-1-yl]-1,3,4-thiadiazole
by: Shiv K. Gupta, et al.
Published: (2011-01-01)

Crystal structure of 1,2-bis(4,5-dinitro-1H-imidazol-1-yl)ethane, C8H6N8O8
by: Yong Wang, et al.
Published: (2022-08-01)

Catalytic efficiency of GO-PANI nanocomposite in the synthesis of N-Aryl-1,4-Dihydropyridine and hydroquinoline derivatives
by: Hossein Ghafuri, et al.
Published: (2025-01-01)

The crystal structure of 3-(carboxymethyl)-1-ethenyl-1H-imidazol-3-ium chloride, C7H9N2O2Cl
by: Song Wenqi, et al.
Published: (2021-09-01)

The crystal structre of 3-(1-ethenyl-1H-imidazol-3-ium-3-yl)propane-1-sulfonate, C8H12N2O3S
by: Zhu Yanfang, et al.
Published: (2021-09-01)

Synthesis and Structure Elucidation of 4-(4-Amino-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl-methylene)-2-phenyl-1H-imidazol-5(4H)-one
by: Hooshang Vahedi, et al.
Published: (2010-01-01)

Synthesis and Pharmacological Evaluation of 2-(4-Halosubstituted phenyl)-4,5-diphenyl-1H-imidazoles
by: G. Nagalakshmi
Published: (2008-01-01)

Synthesis and Evaluation of Antimicrobial Activity of Nitrones from Derivatives of Aryl-Substituted Dihydroisoquinoline
by: Mouna Bouzid, et al.
Published: (2015-01-01)

Evaluation of In Vitro Anti-inflammatory Activity of Azomethines of Aryl Oxazoles
by: V. Niraimathi, et al.
Published: (2011-01-01)

Synthesis and In Vitro Antibacterial Activity of New 2-(1-Methyl-4-nitro-1H-imidazol-5-ylsulfonyl)-1,3,4-thiadiazoles
by: Bahram Letafat, et al.
Published: (2011-01-01)

Molecular Modeling Studies of Substituted 2,4,5-Trisubstituted Triazolinones Aryl and Nonaryl Derivatives as Angiotensin II AT1 Receptor Antagonists
by: Mukesh C. Sharma, et al.
Published: (2013-01-01)

Catalytic pathways for N-arylation of benzimidazoles: A comprehensive review
by: Anila Ghulam, et al.
Published: (2025-01-01)

Laccase cataylzed synthesis of quaternary malononitriles with an aryl substituent
by: Parisa Amani, et al.
Published: (2025-06-01)

Synthesis and Characterization of 9-Phenyl-9H-purin-6-amines from 5-Amino-1-phenyl-1H-imidazole-4-carbonitriles
by: Asieh Yahyazadeh, et al.
Published: (2007-01-01)

Crystal structure of poly[chlorido-μ2-chlorido-(μ2-1-[(2-ethyl-4-methyl-1H-imidazol-1-yl)methyl]-1H-benzotriazole-κN:N’)cadmium(II)], C13H15CdN5Cl2
by: Du Jun-Ya, et al.
Published: (2023-10-01)

Synthesis of Schiff Bases of 2-amino-5-aryl-1,3,4-thiadiazole and Its Analgesic, Anti-Inflammatory and Anti-Bacterial Activity
by: Alok Pandey, et al.
Published: (2012-01-01)

Synthesis and In Vitro Antimicrobial, Anthelmintic and Insecticidal Activities Study of 4(4'-Bromophenyl)-6-substituted-aryl-1-acetyl pyrimidine-2-thiols
by: Rita Bamnela, et al.
Published: (2010-01-01)

The Mitochondria-Targeted Antioxidant SkQ1 Downregulates Aryl Hydrocarbon Receptor-Dependent Genes in the Retina of OXYS Rats with AMD-Like Retinopathy
by: M. L. Perepechaeva, et al.
Published: (2014-01-01)