Glial reactivity and cognitive decline follow chronic heterochromatin loss in neurons

Glial reactivity and cognitive decline follow chronic heterochromatin loss in neurons

Abstract In aging cells and animal models of premature aging, heterochromatin loss coincides with transcriptional disruption including the activation of normally silenced endogenous retroviruses (ERVs). Here we show that loss of heterochromatin maintenance and de-repression of ERVs result in a chron...

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Main Authors: A. G. Newman, J. Sharif, P. Bessa, S. Zaqout, J. P. Brown, D. Richter, R. Dannenberg, M. Nakayama, S. Mueller, T. Schaub, S. Manickaraj, P. Boehm-Sturm, O. Ohara, H. Koseki, P. B. Singh, V. Tarabykin
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61319-7
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https://doi.org/10.1038/s41467-025-61319-7

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