Redefining Onyx HD 500 in the Flow Diversion Era
We report the largest US case series results using Onyx HD-500 (EV3), a new liquid embolic agent, in the successful treatment of 21 patients with wide-neck intracranial aneurysms (mean size 4.5 mm), which are at increased risk of incomplete occlusion or recanalization with standard endovascular inte...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
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| Series: | International Journal of Vascular Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/435490 |
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| _version_ | 1832560839768408064 |
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| author | Richard Tyler Dalyai Ciro Randazzo George Ghobrial L. Fernando Gonzalez Stavropoula I. Tjoumakaris Aaron S. Dumont Robert H. Rosenwasser Pascal Jabbour |
| author_facet | Richard Tyler Dalyai Ciro Randazzo George Ghobrial L. Fernando Gonzalez Stavropoula I. Tjoumakaris Aaron S. Dumont Robert H. Rosenwasser Pascal Jabbour |
| author_sort | Richard Tyler Dalyai |
| collection | DOAJ |
| description | We report the largest US case series results using Onyx HD-500 (EV3), a new liquid embolic agent, in the successful treatment of 21 patients with wide-neck intracranial aneurysms (mean size 4.5 mm), which are at increased risk of incomplete occlusion or recanalization with standard endovascular intervention utilizing detachable platinum coils. All aneurysms were located in the anterior circulation, and three aneurysms presented as acute subarachnoid hemorrhages. Complete aneurysm occlusion was present in 19 of 21 patients (90%). On six-month followup, one patient with an initially small residual neck progressed to total occlusion. Aneurysm recanalization was not detected in any patients on mean follow up of 8.9 months in 11 patients. Four patients experienced transient neurologic deficits in the immediate postoperative period and one in a delayed fashion. Embolization with the liquid embolic agent Onyx appears to be a safe and effective endovascular modality of treatment for wide-neck aneurysms or recurrent aneurysms that had previously failed treatment with detachable coils. |
| format | Article |
| id | doaj-art-e65cf6e91eea4abb818ebb66e19b2f88 |
| institution | Kabale University |
| issn | 2090-2824 2090-2832 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Vascular Medicine |
| spelling | doaj-art-e65cf6e91eea4abb818ebb66e19b2f882025-02-03T01:26:40ZengWileyInternational Journal of Vascular Medicine2090-28242090-28322012-01-01201210.1155/2012/435490435490Redefining Onyx HD 500 in the Flow Diversion EraRichard Tyler Dalyai0Ciro Randazzo1George Ghobrial2L. Fernando Gonzalez3Stavropoula I. Tjoumakaris4Aaron S. Dumont5Robert H. Rosenwasser6Pascal Jabbour7Department of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USADepartment of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USADepartment of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USADepartment of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USADepartment of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USADepartment of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USADepartment of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USADepartment of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USAWe report the largest US case series results using Onyx HD-500 (EV3), a new liquid embolic agent, in the successful treatment of 21 patients with wide-neck intracranial aneurysms (mean size 4.5 mm), which are at increased risk of incomplete occlusion or recanalization with standard endovascular intervention utilizing detachable platinum coils. All aneurysms were located in the anterior circulation, and three aneurysms presented as acute subarachnoid hemorrhages. Complete aneurysm occlusion was present in 19 of 21 patients (90%). On six-month followup, one patient with an initially small residual neck progressed to total occlusion. Aneurysm recanalization was not detected in any patients on mean follow up of 8.9 months in 11 patients. Four patients experienced transient neurologic deficits in the immediate postoperative period and one in a delayed fashion. Embolization with the liquid embolic agent Onyx appears to be a safe and effective endovascular modality of treatment for wide-neck aneurysms or recurrent aneurysms that had previously failed treatment with detachable coils.http://dx.doi.org/10.1155/2012/435490 |
| spellingShingle | Richard Tyler Dalyai Ciro Randazzo George Ghobrial L. Fernando Gonzalez Stavropoula I. Tjoumakaris Aaron S. Dumont Robert H. Rosenwasser Pascal Jabbour Redefining Onyx HD 500 in the Flow Diversion Era International Journal of Vascular Medicine |
| title | Redefining Onyx HD 500 in the Flow Diversion Era |
| title_full | Redefining Onyx HD 500 in the Flow Diversion Era |
| title_fullStr | Redefining Onyx HD 500 in the Flow Diversion Era |
| title_full_unstemmed | Redefining Onyx HD 500 in the Flow Diversion Era |
| title_short | Redefining Onyx HD 500 in the Flow Diversion Era |
| title_sort | redefining onyx hd 500 in the flow diversion era |
| url | http://dx.doi.org/10.1155/2012/435490 |
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