Phagocytosis is the main CR3-mediated function affected by the lupus-associated variant of CD11b in human myeloid cells.

Phagocytosis is the main CR3-mediated function affected by the lupus-associated variant of CD11b in human myeloid cells.

The CD11b/CD18 integrin (complement receptor 3, CR3) is a surface receptor on monocytes, neutrophils, macrophages and dendritic cells that plays a crucial role in several immunological processes including leukocyte extravasation and phagocytosis. The minor allele of a non-synonymous CR3 polymorphism...

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Bibliographic Details
Main Authors: Liliane Fossati-Jimack, Guang Sheng Ling, Andrea Cortini, Marta Szajna, Talat H Malik, Jacqueline U McDonald, Matthew C Pickering, H Terence Cook, Philip R Taylor, Marina Botto
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0057082&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0057082&type=printable

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