Procoagulant Phospholipids and Tissue Factor Activity in Cerebrospinal Fluid from Patients with Intracerebral Haemorrhage
Brain contains large amounts of tissue factor, the major initiator of the coagulation cascade. Neuronal apoptosis after intracerebral haemorrhage (ICH) leads to the shedding of procoagulant phospholipids (PPLs). The aim of this study was to investigate the generation of PPL, tissue factor activity (...
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Wiley
2014-01-01
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| Series: | Advances in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2014/576750 |
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| author | Patrick Van Dreden Guy Hue Jean-François Dreyfus Barry Woodhams Marc Vasse |
| author_facet | Patrick Van Dreden Guy Hue Jean-François Dreyfus Barry Woodhams Marc Vasse |
| author_sort | Patrick Van Dreden |
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| description | Brain contains large amounts of tissue factor, the major initiator of the coagulation cascade. Neuronal apoptosis after intracerebral haemorrhage (ICH) leads to the shedding of procoagulant phospholipids (PPLs). The aim of this study was to investigate the generation of PPL, tissue factor activity (TFa), and D-Dimer (D-Di) in the cerebrospinal fluid (CSF) at the acute phase of ICH in comparison with other brain diseases and to examine the relationship between these factors and the outcome of ICH. CSF was collected from 112 patients within 48 hours of hospital admission. Thirty-one patients with no neurological or biochemical abnormalities were used to establish reference range in the CSF (“controls”). Thirty had suffered an ICH, and 51 other neurological diagnoses [12: ventricular drainage following brain surgery, 13: viral meningitis, 15: bacterial meningitis, and 11 a neurodegenerative disease (NDD)]. PPL was measured using a factor Xa-based coagulation assay and TFa by one home test. PPL, D-Di, and TFa were significantly higher (P<0.001) in the CSF of patients with ICH than in controls. TFa levels were significantly (P<0.05) higher in ICH than in patients with meningitides or NDD. Higher levels (P<0.05) of TFa were observed in patients with ICH who died than in survivors. TFa measurement in the CSF of patients with ICH could constitute a new prognostic marker. |
| format | Article |
| id | doaj-art-e6284fbd79f944e4b270fb7a8f4c745e |
| institution | Kabale University |
| issn | 1687-9104 1687-9112 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
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| spelling | doaj-art-e6284fbd79f944e4b270fb7a8f4c745e2025-02-03T01:21:28ZengWileyAdvances in Hematology1687-91041687-91122014-01-01201410.1155/2014/576750576750Procoagulant Phospholipids and Tissue Factor Activity in Cerebrospinal Fluid from Patients with Intracerebral HaemorrhagePatrick Van Dreden0Guy Hue1Jean-François Dreyfus2Barry Woodhams3Marc Vasse4Diagnostica Stago, 125 Avenue Louis Roche, 92635 Gennevilliers Cedex, FranceBiochemistry Department, IBC, Rouen University Hospital, 76031 Rouen Cedex, FranceClinical Research Unit, Hôpital Foch, University of Versailles, 92151 Suresnes Cedex, FranceHaemaCon Ltd, Bromley, Kent CT18 7TW, UKClinical Biology Department & EA 4531, Hospital Foch, 40 rue Worth, 92151 Suresnes Cedex, FranceBrain contains large amounts of tissue factor, the major initiator of the coagulation cascade. Neuronal apoptosis after intracerebral haemorrhage (ICH) leads to the shedding of procoagulant phospholipids (PPLs). The aim of this study was to investigate the generation of PPL, tissue factor activity (TFa), and D-Dimer (D-Di) in the cerebrospinal fluid (CSF) at the acute phase of ICH in comparison with other brain diseases and to examine the relationship between these factors and the outcome of ICH. CSF was collected from 112 patients within 48 hours of hospital admission. Thirty-one patients with no neurological or biochemical abnormalities were used to establish reference range in the CSF (“controls”). Thirty had suffered an ICH, and 51 other neurological diagnoses [12: ventricular drainage following brain surgery, 13: viral meningitis, 15: bacterial meningitis, and 11 a neurodegenerative disease (NDD)]. PPL was measured using a factor Xa-based coagulation assay and TFa by one home test. PPL, D-Di, and TFa were significantly higher (P<0.001) in the CSF of patients with ICH than in controls. TFa levels were significantly (P<0.05) higher in ICH than in patients with meningitides or NDD. Higher levels (P<0.05) of TFa were observed in patients with ICH who died than in survivors. TFa measurement in the CSF of patients with ICH could constitute a new prognostic marker.http://dx.doi.org/10.1155/2014/576750 |
| spellingShingle | Patrick Van Dreden Guy Hue Jean-François Dreyfus Barry Woodhams Marc Vasse Procoagulant Phospholipids and Tissue Factor Activity in Cerebrospinal Fluid from Patients with Intracerebral Haemorrhage Advances in Hematology |
| title | Procoagulant Phospholipids and Tissue Factor Activity in Cerebrospinal Fluid from Patients with Intracerebral Haemorrhage |
| title_full | Procoagulant Phospholipids and Tissue Factor Activity in Cerebrospinal Fluid from Patients with Intracerebral Haemorrhage |
| title_fullStr | Procoagulant Phospholipids and Tissue Factor Activity in Cerebrospinal Fluid from Patients with Intracerebral Haemorrhage |
| title_full_unstemmed | Procoagulant Phospholipids and Tissue Factor Activity in Cerebrospinal Fluid from Patients with Intracerebral Haemorrhage |
| title_short | Procoagulant Phospholipids and Tissue Factor Activity in Cerebrospinal Fluid from Patients with Intracerebral Haemorrhage |
| title_sort | procoagulant phospholipids and tissue factor activity in cerebrospinal fluid from patients with intracerebral haemorrhage |
| url | http://dx.doi.org/10.1155/2014/576750 |
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