Ionizable polymeric micelles (IPMs) for efficient siRNA delivery

Ionizable polymeric micelles (IPMs) for efficient siRNA delivery

Abstract Lipid nanoparticles (LNPs) are widely used for nucleic acid delivery but face challenges like limited targeting and accelerated blood clearance (ABC) effect. We design three ionizable oligomers (IOs) that, with polylactide-polyethylene glycol (PLA-PEG), form a potential siRNA delivery syste...

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Main Authors: Ziyu Zhou, Yu Feng, Mingzhou Jiang, Zijun Yao, Jing Wang, Feng Pan, Rulan Feng, Chong Zhao, Yinyu Ma, Jinge Zhou, Lei Sun, Xiaotian Sun, Changyou Zhan, Xiao He, Kuan Jiang, Jiahui Yu, Zhiqiang Yan
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-55721-w
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https://doi.org/10.1038/s41467-024-55721-w

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