Phylogenetic dependency networks: inferring patterns of CTL escape and codon covariation in HIV-1 Gag.

Phylogenetic dependency networks: inferring patterns of CTL escape and codon covariation in HIV-1 Gag.

HIV avoids elimination by cytotoxic T-lymphocytes (CTLs) through the evolution of escape mutations. Although there is mounting evidence that these escape pathways are broadly consistent among individuals with similar human leukocyte antigen (HLA) class I alleles, previous population-based studies ha...

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Bibliographic Details
Main Authors: Jonathan M Carlson, Zabrina L Brumme, Christine M Rousseau, Chanson J Brumme, Philippa Matthews, Carl Kadie, James I Mullins, Bruce D Walker, P Richard Harrigan, Philip J R Goulder, David Heckerman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-11-01
Series:PLoS Computational Biology
Online Access:https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000225&type=printable
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