Elevated plasma CXCL12 leads to pain chronicity via positive feedback upregulation of CXCL12/CXCR4 axis in pain synapses

Elevated plasma CXCL12 leads to pain chronicity via positive feedback upregulation of CXCL12/CXCR4 axis in pain synapses

Abstract Background Chronic pain poses a clinical challenge due to its associated costly disability and treatment needs. Determining how pain transitions from acute to chronic is crucial for effective management. Upregulation of the chemokine C-X-C motif ligand 12 (CXCL12) in nociceptive pathway is...

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Main Authors: Shi-Ze Leng, Mei-Jia Fang, Yi-Min Wang, Zhen-Jia Lin, Qian-Yi Li, Ya-Nan Xu, Chun-Lin Mai, Jun-Ya Wan, Yangyinhui Yu, Ming Wei, Ying Li, Yu-Fan Zheng, Kai-Lang Zhang, Ya-Juan Wang, Li-jun Zhou, Zhi Tan, Hui Zhang
Format: Article
Language:English
Published: BMC 2024-12-01
Series:The Journal of Headache and Pain
Subjects:
Pain chronicity
Neuropathic pain
Plasma
CXCL12
Nociceptor plasticity
CXCR4
Online Access:https://doi.org/10.1186/s10194-024-01917-w
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https://doi.org/10.1186/s10194-024-01917-w

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