The combination of rAAV pseudo-lipid nanoparticle and triamcinolone acetonide enables multi-administration to liver

The combination of rAAV pseudo-lipid nanoparticle and triamcinolone acetonide enables multi-administration to liver

The multi-administration of recombinant adeno-associated virus (rAAV) is limited largely by immunological barriers. Herein, a novel strategy, named rAAV pseudo-lipid nanoparticle combined with triamcinolone acetonide (LNP-rAAV + TAC), has been described in mice. We showed successful but low efficien...

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Main Authors: Chunmei Gan, Mi Leng, Yu Liu, Zhaoyue Zheng, Siwu He, Wen Qiao, Lin Xiao, Yao Xiao, Jingya Ye, Lixing Zhou, Jiao Zhou, Boduan Xiao, Wenxin Zhao, Jiamei Yang, Aohan Wu, Huiyuan Zhang, Hongbo Hu, Xiaobo Cen, Zhiyong Qian, Haohao Dong, C. Alexander Valencia, Lunzhi Dai, Hoi Yee Chow, Lei Zhang, Biao Dong
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
recombinant adeno-associated virus
lipid nanoparticle
corticosteroid
immunosuppression
multiple systemic administration
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050124002158
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