Changes in mitochondrial thymidine metabolism and mtDNA copy number during induced pluripotency

Changes in mitochondrial thymidine metabolism and mtDNA copy number during induced pluripotency

Abstract Somatic cell reprogramming into human induced pluripotent stem cells entails significant intracellular changes, including modifications in mitochondrial metabolism and a decrease in mitochondrial DNA copy number. However, the mechanisms underlying this decrease in mitochondrial DNA copy num...

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Main Authors: Hyun Kyu Kim, Yena Song, Minji Kye, Byeongho Yu, Hyung Kyu Choi, Sung-Hwan Moon, Man Ryul Lee
Format: Article
Language:English
Published: Nature Publishing Group 2025-06-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-025-01476-3
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