Accurate identification of primary site in tumors of unknown origin (TUO) using DNA methylation

Abstract Tumors of unknown origin (TUO) generally result in poor patient survival and are clinically difficult to address. Identification of the site of origin in TUO patients is paramount to their improved treatment and survival but is difficult to obtain with current methods. Here, we develop a ra...

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Bibliographic Details
Main Authors: Drew Duckett, Erica R. Vormittag-Nocito, Pouya Jamshidi, Madina Sukhanova, Stephanie Parker, Daniel J. Brat, Lawrence J. Jennings, Lucas Santana-Santos
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-025-00805-z
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