From Chemistry to Pharmacology: Exploring the Anti-Inflammatory and Antioxidant Potential of Novel Dexketoprofen Amide Derivatives

From Chemistry to Pharmacology: Exploring the Anti-Inflammatory and Antioxidant Potential of Novel Dexketoprofen Amide Derivatives

In the present study, five novel dexketoprofen amide derivatives with a free carboxyl group in their side chains were synthesized. The in vivo anti-inflammatory potential of dexketoprofen derivatives was evaluated using a carrageenan-induced paw edema model of acute inflammation. Additionally, the l...

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Bibliographic Details
Main Authors: Marko Karović, Miloš Nikolić, Nikola Nedeljković, Marina Vesović, Marina Nikolić, Marijana Anđić, Nevena Lazarević, Vladimir Jakovljević, Jelena Nedeljković, Sanja Đaković, Jelena Bošković, Vladimir Dobričić
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Antioxidants
Subjects:
dexketoprofen
amide derivatives
paw edema
anti-inflammatory activity
antioxidant activity
COX-1
Online Access:https://www.mdpi.com/2076-3921/14/7/796
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