Dual-responsive nanoscale ultrasound contrast agent as an oxidative stress amplifier for enhanced DNA damage in BRCA-proficient ovarian cancer

Dual-responsive nanoscale ultrasound contrast agent as an oxidative stress amplifier for enhanced DNA damage in BRCA-proficient ovarian cancer

PARP inhibitor (PARPi)-based synthetic lethal therapies have displayed limited benefits in BRCA-proficient ovarian cancer. To potentiate the application of PARPi, an ultrasound contrast agent OLA-NDs for delivery of the PARPi olaparib (OLA) was established for enhancing DNA damage by blocking DNA re...

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Bibliographic Details
Main Authors: Jialu Zhang, Xiaoxuan Wang, Lu Guo, Shan Xiao, Dong Meng, Mengmeng Shang, Xiao Sun, Dandan Shi, Yading Zhao, Rui Liu, Shuting Huang, Xinyu Zeng, Jie Li
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Materials Today Bio
Subjects:
Ovarian cancer
Ultrasound-targeted microbubble destruction
DNA damage
Reactive oxygen species
Mitochondrial dysfunction
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006425003217
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