Mechanisms of muscle repair after peripheral nerve injury by electrical stimulation combined with blood flow restriction training
This review elucidates the impact of electrical stimulation (ES) and blood flow restriction (BFR) training on muscle function. ES induces a transformation in muscle fibers type by rearranging myosin heavy chain isoform patterns. Additionally, it influences muscle protein synthesis and degradation th...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2025-05-01
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| Series: | Sports Medicine and Health Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S266633762400115X |
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| author | Xiaolei Chu Jiaojiao Sun Jiajia Liang Wenjie Liu Zheng Xing Qi Li Qingwen Li |
| author_facet | Xiaolei Chu Jiaojiao Sun Jiajia Liang Wenjie Liu Zheng Xing Qi Li Qingwen Li |
| author_sort | Xiaolei Chu |
| collection | DOAJ |
| description | This review elucidates the impact of electrical stimulation (ES) and blood flow restriction (BFR) training on muscle function. ES induces a transformation in muscle fibers type by rearranging myosin heavy chain isoform patterns. Additionally, it influences muscle protein synthesis and degradation through specific signaling pathways such as protein kinase B/mechanistic target of rapamycin (Akt/mTOR), as well as via autophagy and the ubiquitin-proteasome system, thereby effectively maintaining muscle mass. BFR, on the other hand, restricts muscle blood flow, leading to metabolic products accumulation and localized hypoxia, which not only promotes the recruitment of fast-twitch fibers but also activates the mTOR signaling pathway, enhancing muscle protein synthesis. The combination of ES and BFR synergistically facilitates muscle protein synthesis through the mTOR pathway, thereby accelerating the recovery of muscle function following peripheral nerve injury. |
| format | Article |
| id | doaj-art-e5a2f271d16d4d299b4fda51df6aadd6 |
| institution | Kabale University |
| issn | 2666-3376 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Sports Medicine and Health Science |
| spelling | doaj-art-e5a2f271d16d4d299b4fda51df6aadd62025-02-01T04:12:01ZengKeAi Communications Co., Ltd.Sports Medicine and Health Science2666-33762025-05-0173173184Mechanisms of muscle repair after peripheral nerve injury by electrical stimulation combined with blood flow restriction trainingXiaolei Chu0Jiaojiao Sun1Jiajia Liang2Wenjie Liu3Zheng Xing4Qi Li5Qingwen Li6Department of Rehabilitation, Tianjin University Tianjin Hospital, Tianjin, ChinaTianjin Key, Laboratory of Exercise Physiology and Sports Medicine, Institute of Sport, Exercise and Health, Tianjin University of Sport, Tianjin, ChinaTianjin Key, Laboratory of Exercise Physiology and Sports Medicine, Institute of Sport, Exercise and Health, Tianjin University of Sport, Tianjin, ChinaTianjin Key, Laboratory of Exercise Physiology and Sports Medicine, Institute of Sport, Exercise and Health, Tianjin University of Sport, Tianjin, ChinaDepartment of Rehabilitation, Tianjin University Tianjin Hospital, Tianjin, ChinaDepartment of Rehabilitation, Tianjin University Tianjin Hospital, Tianjin, China; Corresponding author. Department of Rehabilitation, Tianjin University Tianjin Hospital, Tianjin, China.Tianjin Key, Laboratory of Exercise Physiology and Sports Medicine, Institute of Sport, Exercise and Health, Tianjin University of Sport, Tianjin, China; Corresponding author. Tianjin Key, Laboratory of Exercise Physiology and Sports Medicine, Institute of Sport, Exercise and Health, Tianjin University of Sport, Tianjin, China.This review elucidates the impact of electrical stimulation (ES) and blood flow restriction (BFR) training on muscle function. ES induces a transformation in muscle fibers type by rearranging myosin heavy chain isoform patterns. Additionally, it influences muscle protein synthesis and degradation through specific signaling pathways such as protein kinase B/mechanistic target of rapamycin (Akt/mTOR), as well as via autophagy and the ubiquitin-proteasome system, thereby effectively maintaining muscle mass. BFR, on the other hand, restricts muscle blood flow, leading to metabolic products accumulation and localized hypoxia, which not only promotes the recruitment of fast-twitch fibers but also activates the mTOR signaling pathway, enhancing muscle protein synthesis. The combination of ES and BFR synergistically facilitates muscle protein synthesis through the mTOR pathway, thereby accelerating the recovery of muscle function following peripheral nerve injury.http://www.sciencedirect.com/science/article/pii/S266633762400115XElectrical stimulationBlood flow restrictionMuscle fibersmTORMuscle protein synthesis |
| spellingShingle | Xiaolei Chu Jiaojiao Sun Jiajia Liang Wenjie Liu Zheng Xing Qi Li Qingwen Li Mechanisms of muscle repair after peripheral nerve injury by electrical stimulation combined with blood flow restriction training Sports Medicine and Health Science Electrical stimulation Blood flow restriction Muscle fibers mTOR Muscle protein synthesis |
| title | Mechanisms of muscle repair after peripheral nerve injury by electrical stimulation combined with blood flow restriction training |
| title_full | Mechanisms of muscle repair after peripheral nerve injury by electrical stimulation combined with blood flow restriction training |
| title_fullStr | Mechanisms of muscle repair after peripheral nerve injury by electrical stimulation combined with blood flow restriction training |
| title_full_unstemmed | Mechanisms of muscle repair after peripheral nerve injury by electrical stimulation combined with blood flow restriction training |
| title_short | Mechanisms of muscle repair after peripheral nerve injury by electrical stimulation combined with blood flow restriction training |
| title_sort | mechanisms of muscle repair after peripheral nerve injury by electrical stimulation combined with blood flow restriction training |
| topic | Electrical stimulation Blood flow restriction Muscle fibers mTOR Muscle protein synthesis |
| url | http://www.sciencedirect.com/science/article/pii/S266633762400115X |
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