GSK-3β at the Intersection of Neuronal Plasticity and Neurodegeneration
In neurons, Glycogen Synthase Kinase-3β (GSK-3β) has been shown to regulate various critical processes underlying structural and functional synaptic plasticity. Mouse models with neuron-selective expression or deletion of GSK-3β present behavioral and cognitive abnormalities, positioning this protei...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2019/4209475 |
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| author | Tomasz Jaworski Ewa Banach-Kasper Katarzyna Gralec |
| author_facet | Tomasz Jaworski Ewa Banach-Kasper Katarzyna Gralec |
| author_sort | Tomasz Jaworski |
| collection | DOAJ |
| description | In neurons, Glycogen Synthase Kinase-3β (GSK-3β) has been shown to regulate various critical processes underlying structural and functional synaptic plasticity. Mouse models with neuron-selective expression or deletion of GSK-3β present behavioral and cognitive abnormalities, positioning this protein kinase as a key signaling molecule in normal brain functioning. Furthermore, mouse models with defective GSK-3β activity display distinct structural and behavioral abnormalities, which model some aspects of different neurological and neuropsychiatric disorders. Equalizing GSK-3β activity in these mouse models by genetic or pharmacological interventions is able to rescue some of these abnormalities. Thus, GSK-3β is a relevant therapeutic target for the treatment of many brain disorders. Here, we provide an overview of how GSK-3β is regulated in physiological synaptic plasticity and how aberrant GSK-3β activity contributes to the development of dysfunctional synaptic plasticity in neuropsychiatric and neurodegenerative disorders. |
| format | Article |
| id | doaj-art-e59a7cdb7b164014bdd95086d728baf6 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-e59a7cdb7b164014bdd95086d728baf62025-02-03T06:01:10ZengWileyNeural Plasticity2090-59041687-54432019-01-01201910.1155/2019/42094754209475GSK-3β at the Intersection of Neuronal Plasticity and NeurodegenerationTomasz Jaworski0Ewa Banach-Kasper1Katarzyna Gralec2Laboratory of Animal Models, Nencki Institute of Experimental Biology PAS, 02-093 Warsaw, PolandLaboratory of Animal Models, Nencki Institute of Experimental Biology PAS, 02-093 Warsaw, PolandLaboratory of Animal Models, Nencki Institute of Experimental Biology PAS, 02-093 Warsaw, PolandIn neurons, Glycogen Synthase Kinase-3β (GSK-3β) has been shown to regulate various critical processes underlying structural and functional synaptic plasticity. Mouse models with neuron-selective expression or deletion of GSK-3β present behavioral and cognitive abnormalities, positioning this protein kinase as a key signaling molecule in normal brain functioning. Furthermore, mouse models with defective GSK-3β activity display distinct structural and behavioral abnormalities, which model some aspects of different neurological and neuropsychiatric disorders. Equalizing GSK-3β activity in these mouse models by genetic or pharmacological interventions is able to rescue some of these abnormalities. Thus, GSK-3β is a relevant therapeutic target for the treatment of many brain disorders. Here, we provide an overview of how GSK-3β is regulated in physiological synaptic plasticity and how aberrant GSK-3β activity contributes to the development of dysfunctional synaptic plasticity in neuropsychiatric and neurodegenerative disorders.http://dx.doi.org/10.1155/2019/4209475 |
| spellingShingle | Tomasz Jaworski Ewa Banach-Kasper Katarzyna Gralec GSK-3β at the Intersection of Neuronal Plasticity and Neurodegeneration Neural Plasticity |
| title | GSK-3β at the Intersection of Neuronal Plasticity and Neurodegeneration |
| title_full | GSK-3β at the Intersection of Neuronal Plasticity and Neurodegeneration |
| title_fullStr | GSK-3β at the Intersection of Neuronal Plasticity and Neurodegeneration |
| title_full_unstemmed | GSK-3β at the Intersection of Neuronal Plasticity and Neurodegeneration |
| title_short | GSK-3β at the Intersection of Neuronal Plasticity and Neurodegeneration |
| title_sort | gsk 3β at the intersection of neuronal plasticity and neurodegeneration |
| url | http://dx.doi.org/10.1155/2019/4209475 |
| work_keys_str_mv | AT tomaszjaworski gsk3battheintersectionofneuronalplasticityandneurodegeneration AT ewabanachkasper gsk3battheintersectionofneuronalplasticityandneurodegeneration AT katarzynagralec gsk3battheintersectionofneuronalplasticityandneurodegeneration |