Different Angiogenic Potential in Low and High Grade Sporadic Clear Cell Renal Cell Carcinoma Is Not Related to Alterations in the von Hippel–Lindau Gene
Background: von Hippel–Lindau (VHL) inactivation is common in sporadic clear cell renal cell carcinomas (ccRCC). pVHL is part of the ubiquitin ligase complex that targets the alpha subunits of hypoxia-inducible transcription factor (HIF) for degradation under well-oxygenated conditions. In the absen...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Cellular Oncology |
| Online Access: | http://dx.doi.org/10.3233/CLO-2009-0482 |
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| author | Marcella M. Baldewijns Iris J. H. van Vlodrop Kim M. Smits Peter B. Vermeulen Gert G. Van den Eynden Fiona Schot Tania Roskams Hein van Poppel Manon van Engeland Adriaan P. de Bruïne |
| author_facet | Marcella M. Baldewijns Iris J. H. van Vlodrop Kim M. Smits Peter B. Vermeulen Gert G. Van den Eynden Fiona Schot Tania Roskams Hein van Poppel Manon van Engeland Adriaan P. de Bruïne |
| author_sort | Marcella M. Baldewijns |
| collection | DOAJ |
| description | Background: von Hippel–Lindau (VHL) inactivation is common in sporadic clear cell renal cell carcinomas (ccRCC). pVHL is part of the ubiquitin ligase complex that targets the alpha subunits of hypoxia-inducible transcription factor (HIF) for degradation under well-oxygenated conditions. In the absence of wild-type pVHL, as observed in VHL patients and most sporadic ccRCCs, constitutive upregulation of HIF results in transcriptional activation of angiogenesis-related genes, such as VEGF. Differences in angiogenic activity within the group of ccRCCs were reported and strong genotype-phenotype correlations were found in patients with VHL disease, raising a question about the importance of VHL inactivation status in angiogenic behaviour and tumour progression. |
| format | Article |
| id | doaj-art-e578e2c40e7a44fe984e018d2f677923 |
| institution | Kabale University |
| issn | 1570-5870 1875-8606 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cellular Oncology |
| spelling | doaj-art-e578e2c40e7a44fe984e018d2f6779232025-02-03T05:57:10ZengWileyCellular Oncology1570-58701875-86062009-01-0131537138210.3233/CLO-2009-0482Different Angiogenic Potential in Low and High Grade Sporadic Clear Cell Renal Cell Carcinoma Is Not Related to Alterations in the von Hippel–Lindau GeneMarcella M. Baldewijns0Iris J. H. van Vlodrop1Kim M. Smits2Peter B. Vermeulen3Gert G. Van den Eynden4Fiona Schot5Tania Roskams6Hein van Poppel7Manon van Engeland8Adriaan P. de Bruïne9Department of Pathology, GROW-School for Oncology and Developmental Biology, Maastricht University, Maastricht, The NetherlandsDepartment of Pathology, GROW-School for Oncology and Developmental Biology, Maastricht University, Maastricht, The NetherlandsDepartment of Epidemiology, GROW-School for Oncology and Developmental Biology, Maastricht University, Maastricht, The NetherlandsTranslational Cancer Research Group, Lab Pathology University of Antwerp/University Hospital Antwerp, Edegem; Oncology Center, General Hospital St. Augustinus, Wilrijk, BelgiumTranslational Cancer Research Group, Lab Pathology University of Antwerp/University Hospital Antwerp, Edegem; Oncology Center, General Hospital St. Augustinus, Wilrijk, BelgiumDepartment of Pathology, GROW-School for Oncology and Developmental Biology, Maastricht University, Maastricht, The NetherlandsDepartment of Pathology, University Hospital of Leuven, Leuven, BelgiumDepartment of Urology, University Hospital of Leuven, Leuven, BelgiumDepartment of Pathology, GROW-School for Oncology and Developmental Biology, Maastricht University, Maastricht, The NetherlandsDepartment of Pathology, GROW-School for Oncology and Developmental Biology, Maastricht University, Maastricht, The NetherlandsBackground: von Hippel–Lindau (VHL) inactivation is common in sporadic clear cell renal cell carcinomas (ccRCC). pVHL is part of the ubiquitin ligase complex that targets the alpha subunits of hypoxia-inducible transcription factor (HIF) for degradation under well-oxygenated conditions. In the absence of wild-type pVHL, as observed in VHL patients and most sporadic ccRCCs, constitutive upregulation of HIF results in transcriptional activation of angiogenesis-related genes, such as VEGF. Differences in angiogenic activity within the group of ccRCCs were reported and strong genotype-phenotype correlations were found in patients with VHL disease, raising a question about the importance of VHL inactivation status in angiogenic behaviour and tumour progression.http://dx.doi.org/10.3233/CLO-2009-0482 |
| spellingShingle | Marcella M. Baldewijns Iris J. H. van Vlodrop Kim M. Smits Peter B. Vermeulen Gert G. Van den Eynden Fiona Schot Tania Roskams Hein van Poppel Manon van Engeland Adriaan P. de Bruïne Different Angiogenic Potential in Low and High Grade Sporadic Clear Cell Renal Cell Carcinoma Is Not Related to Alterations in the von Hippel–Lindau Gene Cellular Oncology |
| title | Different Angiogenic Potential in Low and High Grade Sporadic Clear Cell Renal Cell Carcinoma Is Not Related to Alterations in the von Hippel–Lindau Gene |
| title_full | Different Angiogenic Potential in Low and High Grade Sporadic Clear Cell Renal Cell Carcinoma Is Not Related to Alterations in the von Hippel–Lindau Gene |
| title_fullStr | Different Angiogenic Potential in Low and High Grade Sporadic Clear Cell Renal Cell Carcinoma Is Not Related to Alterations in the von Hippel–Lindau Gene |
| title_full_unstemmed | Different Angiogenic Potential in Low and High Grade Sporadic Clear Cell Renal Cell Carcinoma Is Not Related to Alterations in the von Hippel–Lindau Gene |
| title_short | Different Angiogenic Potential in Low and High Grade Sporadic Clear Cell Renal Cell Carcinoma Is Not Related to Alterations in the von Hippel–Lindau Gene |
| title_sort | different angiogenic potential in low and high grade sporadic clear cell renal cell carcinoma is not related to alterations in the von hippel lindau gene |
| url | http://dx.doi.org/10.3233/CLO-2009-0482 |
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