Redox-dependent purine degradation triggers postnatal loss of cardiac regeneration potential

Postnatal cardiomyocyte cell cycle withdrawal is a critical step wherein the mammalian heart loses regenerative potential after birth. Here, we conducted interspecies multi-omic comparisons between the mouse heart and that of the opossum, which have different postnatal time-windows for cardiomyocyte...

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Bibliographic Details
Main Authors: Yuichi Saito, Yuki Sugiura, Akane Sakaguchi, Tai Sada, Chihiro Nishiyama, Rae Maeda, Mari Kaneko, Hiroshi Kiyonari, Wataru Kimura
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Redox Biology
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Online Access:http://www.sciencedirect.com/science/article/pii/S2213231724004208
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