FcRn-Driven Nanoengineered Mucosal Vaccine with Multi-Epitope Fusion Induces Robust Dual Immunity and Long-Term Protection Against <i>Brucella</i>

FcRn-Driven Nanoengineered Mucosal Vaccine with Multi-Epitope Fusion Induces Robust Dual Immunity and Long-Term Protection Against <i>Brucella</i>

Background: Brucellosis poses a significant public health challenge, necessitating effective vaccine development. Current vaccines have limitations such as safety concerns and inadequate mucosal immunity. This study aims to develop an FcRn-targeted mucosal <i>Brucella</i> vaccine by fusi...

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Bibliographic Details
Main Authors: Tingting Tian, Yuejie Zhu, Kaiyu Shang, Huidong Shi, Ruixue Xu, Mingzhe Li, Fuling Pu, Junyu Kuang, Jianbing Ding, Fengbo Zhang
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Vaccines
Subjects:
FcRn: neonatal Fc receptor
MEV: multi-epitope vaccine
mucosal vaccine
Online Access:https://www.mdpi.com/2076-393X/13/6/567
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