TNF-Alpha in Peripheral Neuropathy Patients with Impaired Glucose Regulation
Impaired glucose regulation (IGR) is the prestate of diabetes; about 1/3 of IGR patients will develop to diabetes finally. In this study, we investigated the serum tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) levels in peripheral neuropathy impaired patients with impaired glucose reg...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2017/7024024 |
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| author | Xia Li Ju Zhu Na Liu Jie Liu Zhecheng Zhang |
| author_facet | Xia Li Ju Zhu Na Liu Jie Liu Zhecheng Zhang |
| author_sort | Xia Li |
| collection | DOAJ |
| description | Impaired glucose regulation (IGR) is the prestate of diabetes; about 1/3 of IGR patients will develop to diabetes finally. In this study, we investigated the serum tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) levels in peripheral neuropathy impaired patients with impaired glucose regulation (IGR). A total of 70 IGR patients received the conventional nerve conduction test, including 30 patients with peripheral neuropathy (PN) and 40 patients without peripheral neuropathy (NPN). The other 40 healthy individuals were recruited as controls. The serum TNF-α and IL-6 in IGR patients were higher than in control group, and serum TNF-α and IL-6 levels in IGR-PN group were higher than in IGR-NPN group (27.7±17.8 versus 13.1±6.7 pg/mL and 18.1±17.7 versus 6.4±3.7 pg/mL, resp., both p<0.05). Multifactors logistic regression analysis showed that TNF-α (OR = 0.893; p=0.009) was an independent factor affecting whether IGR could combine with peripheral neuropathy. TNF-α and IL-6 could aggregate peripheral neuropathy in impaired glucose regulation patients; TNF-α might be independent risk factor for peripheral neuropathy in glucose regulation impaired patients. |
| format | Article |
| id | doaj-art-e53691615fdc4352aa00d4e3d6bea64f |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-e53691615fdc4352aa00d4e3d6bea64f2025-02-03T05:45:24ZengWileyJournal of Diabetes Research2314-67452314-67532017-01-01201710.1155/2017/70240247024024TNF-Alpha in Peripheral Neuropathy Patients with Impaired Glucose RegulationXia Li0Ju Zhu1Na Liu2Jie Liu3Zhecheng Zhang4The Third Central Clinical College of Tianjin Medical University, Tianjin, ChinaDepartment of Neurology, Tianjin Third Central Hospital, Tianjin, ChinaDepartment of Neurology, Tianjin Third Central Hospital, Tianjin, ChinaDepartment of Neurology, Tianjin Third Central Hospital, Tianjin, ChinaDepartment of Neurology, Tianjin Third Central Hospital, Tianjin, ChinaImpaired glucose regulation (IGR) is the prestate of diabetes; about 1/3 of IGR patients will develop to diabetes finally. In this study, we investigated the serum tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) levels in peripheral neuropathy impaired patients with impaired glucose regulation (IGR). A total of 70 IGR patients received the conventional nerve conduction test, including 30 patients with peripheral neuropathy (PN) and 40 patients without peripheral neuropathy (NPN). The other 40 healthy individuals were recruited as controls. The serum TNF-α and IL-6 in IGR patients were higher than in control group, and serum TNF-α and IL-6 levels in IGR-PN group were higher than in IGR-NPN group (27.7±17.8 versus 13.1±6.7 pg/mL and 18.1±17.7 versus 6.4±3.7 pg/mL, resp., both p<0.05). Multifactors logistic regression analysis showed that TNF-α (OR = 0.893; p=0.009) was an independent factor affecting whether IGR could combine with peripheral neuropathy. TNF-α and IL-6 could aggregate peripheral neuropathy in impaired glucose regulation patients; TNF-α might be independent risk factor for peripheral neuropathy in glucose regulation impaired patients.http://dx.doi.org/10.1155/2017/7024024 |
| spellingShingle | Xia Li Ju Zhu Na Liu Jie Liu Zhecheng Zhang TNF-Alpha in Peripheral Neuropathy Patients with Impaired Glucose Regulation Journal of Diabetes Research |
| title | TNF-Alpha in Peripheral Neuropathy Patients with Impaired Glucose Regulation |
| title_full | TNF-Alpha in Peripheral Neuropathy Patients with Impaired Glucose Regulation |
| title_fullStr | TNF-Alpha in Peripheral Neuropathy Patients with Impaired Glucose Regulation |
| title_full_unstemmed | TNF-Alpha in Peripheral Neuropathy Patients with Impaired Glucose Regulation |
| title_short | TNF-Alpha in Peripheral Neuropathy Patients with Impaired Glucose Regulation |
| title_sort | tnf alpha in peripheral neuropathy patients with impaired glucose regulation |
| url | http://dx.doi.org/10.1155/2017/7024024 |
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