The association between oxidative balance score and all-cause and cardiovascular mortality in patients with arthritis: a retrospective cohort study based on the NHANES database (1999–2018)
Abstract Background and objective No study examined the association of the oxidative balance score (OBS) with mortality in patients with arthritis. This study examined the association between OBS and all-cause and cardiovascular mortality in patients with arthritis. Methods From NHANES, 11,754 patie...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-08-01
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| Series: | BMC Public Health |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12889-025-24041-z |
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| Summary: | Abstract Background and objective No study examined the association of the oxidative balance score (OBS) with mortality in patients with arthritis. This study examined the association between OBS and all-cause and cardiovascular mortality in patients with arthritis. Methods From NHANES, 11,754 patients with arthritis were included. The patients were from the 1999–2018 period. The OBS was calculated using 16 nutrients and four lifestyle factors. The outcomes were all-cause mortality and cardiovascular diseases (CVD) mortality. CVD mortality was defined as death from ICD-10 codes I00-I09, I11, I13, and I20-I51. The Kaplan-Meier analysis and log-rank test were used to depict the survival rate disparities among different groups of patients. The associations of various variables with all-cause mortality and CVD mortality were evaluated using three multivariable Cox regression models. Results The cohort study included 11,754 patients with arthritis, with a mean (SE) age 59.41 (0.22) years and 4,871 men (weighted, 41.44%). Kaplan-Meier analysis showed lower OBS scores are associated with higher overall mortality and CVD mortality (p < 0.001). Multivariable Cox proportional hazard regression model analysis showed that, after adjusting for multiple confounders, the highest OBS quartile had 30% lower all-cause mortality risk (HR = 0.70, 95%CI: 0.58–0.85) and CVD mortality (HR = 0.70, 95%CI: 0.58–0.85, P < 0.001), compared with the lowest quartile. Restricted cubic spline (RCS) curves showed a negative linear association between OBS and both mortality types (p < 0.001). Similar trends were observed for the lifestyle OBS, while dietary OBS showed no independent inverse association on both mortality types in fully adjusted models. Conclusion Higher OBS might be associated with lower all-cause and cardiovascular mortality in patients with arthritis, highlighting the importance of adhering to an antioxidant lifestyle in patients with arthritis. |
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| ISSN: | 1471-2458 |