An immune-based predictive model for HBV clearance: validation in multicenter cohorts and mechanistic insights from in vivo studies

Abstract Background Chronic HBV infection is a major risk factor for hepatocellular carcinoma, posing a significant global health burden. However, predictive models for HBV clearance based on immune biomarkers remain limited. Methods We systematically developed a predictive tool by quantifying mRNA...

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Bibliographic Details
Main Authors: Rongzheng Zhang, Han Qiao, Kun Zhou, Xiaomei Ju, Xinyang Cao, Jianming Dong, Meng Wu, Le Yu, Shuyun Zhang
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Virology Journal
Online Access:https://doi.org/10.1186/s12985-025-02792-w
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