A Review on JC Virus Infection in Kidney Transplant Recipients
The polyomavirus (PyV), JC virus (JCV), is a small nonenveloped DNA virus that asymptomatically infects about 80% of healthy adults and establishes latency in the kidney tissue. In case of immunodeficient hosts, JCV can lytically infect the oligodendrocytes, causing a fatal demyelinating disease, kn...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/926391 |
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| author | Serena Delbue Mariano Ferraresso Luciana Ghio Camilla Carloni Silvia Carluccio Mirco Belingheri Alberto Edefonti Pasquale Ferrante |
| author_facet | Serena Delbue Mariano Ferraresso Luciana Ghio Camilla Carloni Silvia Carluccio Mirco Belingheri Alberto Edefonti Pasquale Ferrante |
| author_sort | Serena Delbue |
| collection | DOAJ |
| description | The polyomavirus (PyV), JC virus (JCV), is a small nonenveloped DNA virus that asymptomatically infects about 80% of healthy adults and establishes latency in the kidney tissue. In case of immunodeficient hosts, JCV can lytically infect the oligodendrocytes, causing a fatal demyelinating disease, known as progressive multifocal leukoencephalopathy (PML). Although the reactivation of another human PyV, BK virus (BKV), is relatively common and its association with the polyomavirus associated nephropathy (PyVAN) following renal transplantation is proven, JCV replication and its impact on graft function and survival are less well studied. Here we describe the biology of JCV and its pathological features and we review the literature regarding the JCV infection analyzed in the setting of transplantations. |
| format | Article |
| id | doaj-art-e52e162dba714e108d06c46c6d9e6e8c |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-e52e162dba714e108d06c46c6d9e6e8c2025-02-03T01:26:32ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/926391926391A Review on JC Virus Infection in Kidney Transplant RecipientsSerena Delbue0Mariano Ferraresso1Luciana Ghio2Camilla Carloni3Silvia Carluccio4Mirco Belingheri5Alberto Edefonti6Pasquale Ferrante7Laboratory of Translational Research, Health Science Foundation “Ettore Sansavini”, Corso Garibaldi 11, 48022 Lugo, ItalyDepartment of General and Vascular Surgery, St. Joseph Hospital, Via San Vittore 12, 20122 Milan, ItalyPediatric Nephrology and Dialysis Unit, IRCCS Ca’ Granda Foundation “Ospedale Maggiore Policlinico”, Via Francesco Sforza 35, 20122 Milan, ItalyLaboratory of Translational Research, Department of Biomedical, Surgical and Dental Sciences, University of Milan, Via Pascal 36, 20133 Milan, ItalyLaboratory of Translational Research, Department of Biomedical, Surgical and Dental Sciences, University of Milan, Via Pascal 36, 20133 Milan, ItalyPediatric Nephrology and Dialysis Unit, IRCCS Ca’ Granda Foundation “Ospedale Maggiore Policlinico”, Via Francesco Sforza 35, 20122 Milan, ItalyPediatric Nephrology and Dialysis Unit, IRCCS Ca’ Granda Foundation “Ospedale Maggiore Policlinico”, Via Francesco Sforza 35, 20122 Milan, ItalyLaboratory of Translational Research, Department of Biomedical, Surgical and Dental Sciences, University of Milan, Via Pascal 36, 20133 Milan, ItalyThe polyomavirus (PyV), JC virus (JCV), is a small nonenveloped DNA virus that asymptomatically infects about 80% of healthy adults and establishes latency in the kidney tissue. In case of immunodeficient hosts, JCV can lytically infect the oligodendrocytes, causing a fatal demyelinating disease, known as progressive multifocal leukoencephalopathy (PML). Although the reactivation of another human PyV, BK virus (BKV), is relatively common and its association with the polyomavirus associated nephropathy (PyVAN) following renal transplantation is proven, JCV replication and its impact on graft function and survival are less well studied. Here we describe the biology of JCV and its pathological features and we review the literature regarding the JCV infection analyzed in the setting of transplantations.http://dx.doi.org/10.1155/2013/926391 |
| spellingShingle | Serena Delbue Mariano Ferraresso Luciana Ghio Camilla Carloni Silvia Carluccio Mirco Belingheri Alberto Edefonti Pasquale Ferrante A Review on JC Virus Infection in Kidney Transplant Recipients Clinical and Developmental Immunology |
| title | A Review on JC Virus Infection in Kidney Transplant Recipients |
| title_full | A Review on JC Virus Infection in Kidney Transplant Recipients |
| title_fullStr | A Review on JC Virus Infection in Kidney Transplant Recipients |
| title_full_unstemmed | A Review on JC Virus Infection in Kidney Transplant Recipients |
| title_short | A Review on JC Virus Infection in Kidney Transplant Recipients |
| title_sort | review on jc virus infection in kidney transplant recipients |
| url | http://dx.doi.org/10.1155/2013/926391 |
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