Fungal β-glucan instructed miR-32-5p modulates Dectin-1 signaling mediated inflammation, reactive oxygen species and apoptosis through polarization of “M2a-like” macrophage in Candida colitis

Fungal β-glucan instructed miR-32-5p modulates Dectin-1 signaling mediated inflammation, reactive oxygen species and apoptosis through polarization of “M2a-like” macrophage in Candida colitis

Ulcerative colitis (UC) is a chronic and easy-to-relapse intestinal disease characterized by colon inflammation and microbial dysbiosis. Candida albicans is the most common fungal resident in the human gut. Overgrowth of C. albicans has been linked to the aggravation of UC. Previously, we demonstrat...

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Bibliographic Details
Main Authors: Liu Yang, Chengcheng Liu, Hanyu Zhu, Zixu Wang, Qinai Luo, Yuzhe Huang, Hao Wang, Min Hu, Jing Shao
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Virulence
Subjects:
Ulcerative colitis
Candida albicans
β-glucan
Dectin-1
miR-32-5p
oxidative stress
Online Access:https://www.tandfonline.com/doi/10.1080/21505594.2025.2514789
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https://www.tandfonline.com/doi/10.1080/21505594.2025.2514789

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