Mechanistic evaluation of a traditional herbal decoction in attenuating hepatic fibrosis via Nrf2/GPX4 pathway activation and ferroptosis inhibition

Mechanistic evaluation of a traditional herbal decoction in attenuating hepatic fibrosis via Nrf2/GPX4 pathway activation and ferroptosis inhibition

Abstract Background Hepatic fibrosis, a progressive fibrotic response to chronic liver injury, is characterized by excessive collagen deposition and impaired tissue repair. This pathological process leads to liver dysfunction and potential progression to irreversible cirrhosis or hepatocellular carc...

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Main Authors: Jing-Jing Liu, Xiao-qi Zhou, Jia-Lin Zhou, Li-Jun Tong, Ling-Xiang Hu, Xiang Liu, Li-Mei Hu, Chang-Xiao Zhou, Qi Dai
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Hereditas
Subjects:
Autophagy
Blood circulation
Ferroptosis
Hepatic fibrosis
Herbal decoction promoting qi, NRF2/GPX4
Water excretion
Online Access:https://doi.org/10.1186/s41065-025-00471-y
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https://doi.org/10.1186/s41065-025-00471-y

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