Cardiorespiratory-gated cardiac proton radiotherapy using a novel ultrasound guidance system
Cardiac stereotactic body radiotherapy is a promising noninvasive treatment for patients with refractory ventricular tachycardia. With the aim to prove feasibility of a novel image guided radiotherapy and heart motion gating device, cardiac proton radiotherapy was performed using a porcine model. Us...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Clinical and Translational Radiation Oncology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405630824001812 |
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| _version_ | 1832582203148599296 |
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| author | Keith A Cengel Zayne Belal Michele M Kim Sarah Hagan Saskia Camps Alexander Kalinin Weihow Hsue Eric Diffenderfer Adriano Garonna Cory Tschabrunn |
| author_facet | Keith A Cengel Zayne Belal Michele M Kim Sarah Hagan Saskia Camps Alexander Kalinin Weihow Hsue Eric Diffenderfer Adriano Garonna Cory Tschabrunn |
| author_sort | Keith A Cengel |
| collection | DOAJ |
| description | Cardiac stereotactic body radiotherapy is a promising noninvasive treatment for patients with refractory ventricular tachycardia. With the aim to prove feasibility of a novel image guided radiotherapy and heart motion gating device, cardiac proton radiotherapy was performed using a porcine model. Using a novel adaptation of γ − H2AX tissue staining techniques, we have been able to localize a radiation beam in large animal tissue to assess targeting accuracy within a defined field. Cardiorespiratory-gated irradiations of the animals were successfully completed and analysis of the γ-H2AX staining intensity of the excised heart after radiation demonstrated radiotherapy was delivered close to or within the expected region. We simulated the irradiated volumes under different gating scenarios, showing significant reduction when using combined cardiorespiratory gating. The results of this study show the feasibility of proton irradiation of the heart left ventricle with a novel ultrasound based cardiorespiratory gating technology with the benefit of reduced irradiation volumes and increased healthy tissue sparing. |
| format | Article |
| id | doaj-art-e4b6eb843d314a80b9994af2d6508742 |
| institution | Kabale University |
| issn | 2405-6308 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical and Translational Radiation Oncology |
| spelling | doaj-art-e4b6eb843d314a80b9994af2d65087422025-01-30T05:14:27ZengElsevierClinical and Translational Radiation Oncology2405-63082025-03-0151100904Cardiorespiratory-gated cardiac proton radiotherapy using a novel ultrasound guidance systemKeith A Cengel0Zayne Belal1Michele M Kim2Sarah Hagan3Saskia Camps4Alexander Kalinin5Weihow Hsue6Eric Diffenderfer7Adriano Garonna8Cory Tschabrunn9Department of Radiation Oncology, University of Pennsylvania, Philadelphia, USA; Corresponding author.Department of Radiation Oncology, University of Pennsylvania, Philadelphia, USADepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, USADepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, USAEBAMed SA, Geneva, SwitzerlandEBAMed SA, Geneva, SwitzerlandSmilow Center for Translational Research, Room 8-136, Univ of Pennsylvania, Perelman School of Medicine, 3400 Civic Center Blvd, Bldg 421, Philadelphia, PA 19104, USADepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, USAEBAMed SA, Geneva, SwitzerlandSmilow Center for Translational Research, Room 8-136, Univ of Pennsylvania, Perelman School of Medicine, 3400 Civic Center Blvd, Bldg 421, Philadelphia, PA 19104, USA; Electrophysiology Section, Division of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USACardiac stereotactic body radiotherapy is a promising noninvasive treatment for patients with refractory ventricular tachycardia. With the aim to prove feasibility of a novel image guided radiotherapy and heart motion gating device, cardiac proton radiotherapy was performed using a porcine model. Using a novel adaptation of γ − H2AX tissue staining techniques, we have been able to localize a radiation beam in large animal tissue to assess targeting accuracy within a defined field. Cardiorespiratory-gated irradiations of the animals were successfully completed and analysis of the γ-H2AX staining intensity of the excised heart after radiation demonstrated radiotherapy was delivered close to or within the expected region. We simulated the irradiated volumes under different gating scenarios, showing significant reduction when using combined cardiorespiratory gating. The results of this study show the feasibility of proton irradiation of the heart left ventricle with a novel ultrasound based cardiorespiratory gating technology with the benefit of reduced irradiation volumes and increased healthy tissue sparing.http://www.sciencedirect.com/science/article/pii/S2405630824001812Cardiac radiationGatingUltrasound guidance |
| spellingShingle | Keith A Cengel Zayne Belal Michele M Kim Sarah Hagan Saskia Camps Alexander Kalinin Weihow Hsue Eric Diffenderfer Adriano Garonna Cory Tschabrunn Cardiorespiratory-gated cardiac proton radiotherapy using a novel ultrasound guidance system Clinical and Translational Radiation Oncology Cardiac radiation Gating Ultrasound guidance |
| title | Cardiorespiratory-gated cardiac proton radiotherapy using a novel ultrasound guidance system |
| title_full | Cardiorespiratory-gated cardiac proton radiotherapy using a novel ultrasound guidance system |
| title_fullStr | Cardiorespiratory-gated cardiac proton radiotherapy using a novel ultrasound guidance system |
| title_full_unstemmed | Cardiorespiratory-gated cardiac proton radiotherapy using a novel ultrasound guidance system |
| title_short | Cardiorespiratory-gated cardiac proton radiotherapy using a novel ultrasound guidance system |
| title_sort | cardiorespiratory gated cardiac proton radiotherapy using a novel ultrasound guidance system |
| topic | Cardiac radiation Gating Ultrasound guidance |
| url | http://www.sciencedirect.com/science/article/pii/S2405630824001812 |
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