Astrocytic AEG-1 drives neuroinflammation and enhances seizure susceptibility

Astrocytic AEG-1 drives neuroinflammation and enhances seizure susceptibility

Astrocyte-elevated gene-1 (AEG-1), also known as metadherin (MTDH) has emerged as a potent oncogene expressed in cancers. An increasing body of evidence indicates AEG-1 plays a pivotal role in various brain pathophysiological processes. Abnormal expression of AEG-1 in astrocytes has been correlated...

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Bibliographic Details
Main Authors: Yuzhou Chen, Yunbo Yu, Jinhao Kou, Honggang Qi, Canyu Zhang, Feiyu Wang, Lijie Zhou, Xuemei Liang, Kang Xu, Cong Zhang, Aifeng Zhang, Xiufang Liu, Chenchen Zhang, Guangming Gan, Jie Sun, Xinjian Zhu
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Neurobiology of Disease
Subjects:
Astrocyte
AEG-1
LPS
Neuroinflammation
Seizure
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996125001731
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