Conformational changes in the motor ATPase CpaF facilitate a rotary mechanism of Tad pilus assembly

Conformational changes in the motor ATPase CpaF facilitate a rotary mechanism of Tad pilus assembly

Abstract The type IV pilus family uses PilT/VirB11-like ATPases to rapidly assemble and disassemble pilin subunits. Among these, the tight adherence (Tad) pilus performs both functions using a single bifunctional ATPase, CpaF. Here, we determine three conformationally distinct structures of CpaF hex...

Full description

Saved in:
Bibliographic Details
Main Authors: Ian Y. Yen, Gregory B. Whitfield, John L. Rubinstein, Lori L. Burrows, Yves V. Brun, P. Lynne Howell
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59009-5
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items