Treacle’s ability to form liquid-like phase condensates is essential for nucleolar fibrillar center assembly, efficient rRNA transcription and processing, and rRNA gene repair

Treacle’s ability to form liquid-like phase condensates is essential for nucleolar fibrillar center assembly, efficient rRNA transcription and processing, and rRNA gene repair

We investigated the role of the nucleolar protein Treacle in organizing and regulating the nucleolus in human cells. Our results support Treacle’s ability to form liquid-like phase condensates through electrostatic interactions among molecules. The formation of these biomolecular condensates is cruc...

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Bibliographic Details
Main Authors: Artem K Velichko, Nadezhda V Petrova, Dmitry A Deriglazov, Anastasia P Kovina, Artem V Luzhin, Eugene P Kazakov, Igor I Kireev, Sergey Razin, Omar L Kantidze
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-04-01
Series:eLife
Subjects:
HeLa
nucleolus
fibrillar centers
Treacle
condensation
phase separation
Online Access:https://elifesciences.org/articles/96722
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https://elifesciences.org/articles/96722

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