Cerebrospinal Fluid BACE1 Activity and Brain Amyloid Load in Alzheimer's Disease
The secretase BACE1 is fundamentally involved in the development of cerebral amyloid pathology in Alzheimer's disease (AD). It has not been studied so far to what extent BACE1 activity in cerebrospinal fluid (CSF) mirrors in vivo amyloid load in AD. We explored associations between CSF BACE1 ac...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/712048 |
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| author | Timo Grimmer Panagiotis Alexopoulos Amalia Tsolakidou Liang-Hao Guo Gjermund Henriksen Behrooz H. Yousefi Hans Förstl Christian Sorg Alexander Kurz Alexander Drzezga Robert Perneczky |
| author_facet | Timo Grimmer Panagiotis Alexopoulos Amalia Tsolakidou Liang-Hao Guo Gjermund Henriksen Behrooz H. Yousefi Hans Förstl Christian Sorg Alexander Kurz Alexander Drzezga Robert Perneczky |
| author_sort | Timo Grimmer |
| collection | DOAJ |
| description | The secretase BACE1 is fundamentally involved in the development of cerebral amyloid pathology in Alzheimer's disease (AD). It has not been studied so far to what extent BACE1 activity in cerebrospinal fluid (CSF) mirrors in vivo amyloid load in AD. We explored associations between CSF BACE1 activity and fibrillar amyloid pathology as measured by carbon-11-labelled Pittsburgh Compound B positron emission tomography ([11C]PIB PET). [11C]PIB and CSF studies were performed in 31 patients with AD. Voxel-based linear regression analysis revealed significant associations between CSF BACE1 activity and [11C]PIB tracer uptake in the bilateral parahippocampal region, the thalamus, and the pons. Our study provides evidence for a brain region-specific correlation between CSF BACE1 activity and in-vivo fibrillar amyloid pathology in AD. Associations were found in areas close to the brain ventricles, which may have important implications for the use of BACE1 in CSF as a marker for AD pathology and for antiamyloid treatment monitoring. |
| format | Article |
| id | doaj-art-e497333714094bff8cc3e5efbaabd8c0 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-e497333714094bff8cc3e5efbaabd8c02025-02-03T05:48:04ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/712048712048Cerebrospinal Fluid BACE1 Activity and Brain Amyloid Load in Alzheimer's DiseaseTimo Grimmer0Panagiotis Alexopoulos1Amalia Tsolakidou2Liang-Hao Guo3Gjermund Henriksen4Behrooz H. Yousefi5Hans Förstl6Christian Sorg7Alexander Kurz8Alexander Drzezga9Robert Perneczky10Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische Universität München, Ismaninger Street 22, 81675 München, GermanyDepartment of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische Universität München, Ismaninger Street 22, 81675 München, GermanyDepartment of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische Universität München, Ismaninger Street 22, 81675 München, GermanyDepartment of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische Universität München, Ismaninger Street 22, 81675 München, GermanyDepartment of Nuclear Medicine, Klinikum rechts der Isar, Technische Universität München, Ismaninger Street 22, 81675 München, GermanyDepartment of Nuclear Medicine, Klinikum rechts der Isar, Technische Universität München, Ismaninger Street 22, 81675 München, GermanyDepartment of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische Universität München, Ismaninger Street 22, 81675 München, GermanyDepartment of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische Universität München, Ismaninger Street 22, 81675 München, GermanyDepartment of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische Universität München, Ismaninger Street 22, 81675 München, GermanyDepartment of Nuclear Medicine, Klinikum rechts der Isar, Technische Universität München, Ismaninger Street 22, 81675 München, GermanyDepartment of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische Universität München, Ismaninger Street 22, 81675 München, GermanyThe secretase BACE1 is fundamentally involved in the development of cerebral amyloid pathology in Alzheimer's disease (AD). It has not been studied so far to what extent BACE1 activity in cerebrospinal fluid (CSF) mirrors in vivo amyloid load in AD. We explored associations between CSF BACE1 activity and fibrillar amyloid pathology as measured by carbon-11-labelled Pittsburgh Compound B positron emission tomography ([11C]PIB PET). [11C]PIB and CSF studies were performed in 31 patients with AD. Voxel-based linear regression analysis revealed significant associations between CSF BACE1 activity and [11C]PIB tracer uptake in the bilateral parahippocampal region, the thalamus, and the pons. Our study provides evidence for a brain region-specific correlation between CSF BACE1 activity and in-vivo fibrillar amyloid pathology in AD. Associations were found in areas close to the brain ventricles, which may have important implications for the use of BACE1 in CSF as a marker for AD pathology and for antiamyloid treatment monitoring.http://dx.doi.org/10.1100/2012/712048 |
| spellingShingle | Timo Grimmer Panagiotis Alexopoulos Amalia Tsolakidou Liang-Hao Guo Gjermund Henriksen Behrooz H. Yousefi Hans Förstl Christian Sorg Alexander Kurz Alexander Drzezga Robert Perneczky Cerebrospinal Fluid BACE1 Activity and Brain Amyloid Load in Alzheimer's Disease The Scientific World Journal |
| title | Cerebrospinal Fluid BACE1 Activity and Brain Amyloid Load in Alzheimer's Disease |
| title_full | Cerebrospinal Fluid BACE1 Activity and Brain Amyloid Load in Alzheimer's Disease |
| title_fullStr | Cerebrospinal Fluid BACE1 Activity and Brain Amyloid Load in Alzheimer's Disease |
| title_full_unstemmed | Cerebrospinal Fluid BACE1 Activity and Brain Amyloid Load in Alzheimer's Disease |
| title_short | Cerebrospinal Fluid BACE1 Activity and Brain Amyloid Load in Alzheimer's Disease |
| title_sort | cerebrospinal fluid bace1 activity and brain amyloid load in alzheimer s disease |
| url | http://dx.doi.org/10.1100/2012/712048 |
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