Nucleophilic addition promoted ring rearrangement-aromatization in aza-/thio-sesquiterpenoid biosynthesis

Abstract The aromatization of terpenoid scaffold has received enduring attention as it introduces diverse structural alterations and endows bioactivity to the molecules. In this study, we discover a unique aromatization mechanism involving consecutive [1,2]-alkyl migrations initiated by intramolecul...

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Main Authors: Hengyi Xu, Xianyan Zhang, Yawen Zhang, Guowei Liu, Yinghan Chen, Xuewen Hou, Xiaolin Liu, Kaijin Zhang, Chuanteng Ma, Ruqian Feng, Juan Shen, Blaine A. Pfeifer, Qian Che, Tianjiao Zhu, Guojian Zhang
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62075-4
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