Study on Lesion Assessment of Cerebello-Thalamo-Cortical Network in Wilson’s Disease with Diffusion Tensor Imaging
Wilson’s disease (WD) is a genetic disorder of copper metabolism with pathological copper accumulation in the brain and any other tissues. This article aimed to assess lesions in cerebello-thalamo-cortical network with an advanced technique of diffusion tensor imaging (DTI) in WD. 35 WD patients and...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2017/7323121 |
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| author | Anqin Wang Hongli Wu Chunsheng Xu Lanfeng Tang Jaeyoun Lee Min Wang Man Jiang Chuanfu Li Qi Lu Chunyun Zhang |
| author_facet | Anqin Wang Hongli Wu Chunsheng Xu Lanfeng Tang Jaeyoun Lee Min Wang Man Jiang Chuanfu Li Qi Lu Chunyun Zhang |
| author_sort | Anqin Wang |
| collection | DOAJ |
| description | Wilson’s disease (WD) is a genetic disorder of copper metabolism with pathological copper accumulation in the brain and any other tissues. This article aimed to assess lesions in cerebello-thalamo-cortical network with an advanced technique of diffusion tensor imaging (DTI) in WD. 35 WD patients and 30 age- and sex-matched healthy volunteers were recruited to accept diffusion-weighted images with 15 gradient vectors and conventional magnetic resonance imaging (MRI). The DTI parameters, including fractional anisotropy (FA) and mean diffusion (MD), were calculated by diffusion kurtosis estimator software. After registration, patient groups with FA mappings and MD mappings and normal groups were compared with 3dttest and receiver-operating characteristic (ROC) curve analysis, corrected with FDR simulations (p=0.001, α=0.05, cluster size = 326). We found that the degree of FA increased in the bilateral head of the caudate nucleus (HCN), lenticular nucleus (LN), ventral thalamus, substantia nigra (SN), red nucleus (RN), right dentate nucleus (DN), and decreased in the mediodorsal thalamus and extensive white matter. The value of MD increased in HCN, LN, SN, RN, and extensive white matter. The technique of DTI provides higher sensitivity and specificity than conventional MRI to detect Wilson’s disease. Besides, lesions in the basal ganglia, thalamus, and cerebellum might disconnect the basal ganglia-thalamo-cortical circuits or dentato-rubro-thalamic (DRT) track and disrupt cerebello-thalamo-cortical network finally, which may cause clinical extrapyramidal symptoms. |
| format | Article |
| id | doaj-art-e48c5b1221cb45659bfc4d04bfca8af8 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-e48c5b1221cb45659bfc4d04bfca8af82025-02-03T06:14:03ZengWileyNeural Plasticity2090-59041687-54432017-01-01201710.1155/2017/73231217323121Study on Lesion Assessment of Cerebello-Thalamo-Cortical Network in Wilson’s Disease with Diffusion Tensor ImagingAnqin Wang0Hongli Wu1Chunsheng Xu2Lanfeng Tang3Jaeyoun Lee4Min Wang5Man Jiang6Chuanfu Li7Qi Lu8Chunyun Zhang9The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui 230012, ChinaLaboratory of Digital Medical Imaging, Medical Imaging Center, Hefei, Anhui 230012, ChinaThe First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui 230012, ChinaLaboratory of Digital Medical Imaging, Medical Imaging Center, Hefei, Anhui 230012, ChinaLaboratory of Digital Medical Imaging, Medical Imaging Center, Hefei, Anhui 230012, ChinaMedical Information Engineering, Anhui University of Chinese Medicine, Hefei, Anhui 230012, ChinaMedical Information Engineering, Anhui University of Chinese Medicine, Hefei, Anhui 230012, ChinaThe First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui 230012, ChinaThe First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui 230012, ChinaThe First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui 230012, ChinaWilson’s disease (WD) is a genetic disorder of copper metabolism with pathological copper accumulation in the brain and any other tissues. This article aimed to assess lesions in cerebello-thalamo-cortical network with an advanced technique of diffusion tensor imaging (DTI) in WD. 35 WD patients and 30 age- and sex-matched healthy volunteers were recruited to accept diffusion-weighted images with 15 gradient vectors and conventional magnetic resonance imaging (MRI). The DTI parameters, including fractional anisotropy (FA) and mean diffusion (MD), were calculated by diffusion kurtosis estimator software. After registration, patient groups with FA mappings and MD mappings and normal groups were compared with 3dttest and receiver-operating characteristic (ROC) curve analysis, corrected with FDR simulations (p=0.001, α=0.05, cluster size = 326). We found that the degree of FA increased in the bilateral head of the caudate nucleus (HCN), lenticular nucleus (LN), ventral thalamus, substantia nigra (SN), red nucleus (RN), right dentate nucleus (DN), and decreased in the mediodorsal thalamus and extensive white matter. The value of MD increased in HCN, LN, SN, RN, and extensive white matter. The technique of DTI provides higher sensitivity and specificity than conventional MRI to detect Wilson’s disease. Besides, lesions in the basal ganglia, thalamus, and cerebellum might disconnect the basal ganglia-thalamo-cortical circuits or dentato-rubro-thalamic (DRT) track and disrupt cerebello-thalamo-cortical network finally, which may cause clinical extrapyramidal symptoms.http://dx.doi.org/10.1155/2017/7323121 |
| spellingShingle | Anqin Wang Hongli Wu Chunsheng Xu Lanfeng Tang Jaeyoun Lee Min Wang Man Jiang Chuanfu Li Qi Lu Chunyun Zhang Study on Lesion Assessment of Cerebello-Thalamo-Cortical Network in Wilson’s Disease with Diffusion Tensor Imaging Neural Plasticity |
| title | Study on Lesion Assessment of Cerebello-Thalamo-Cortical Network in Wilson’s Disease with Diffusion Tensor Imaging |
| title_full | Study on Lesion Assessment of Cerebello-Thalamo-Cortical Network in Wilson’s Disease with Diffusion Tensor Imaging |
| title_fullStr | Study on Lesion Assessment of Cerebello-Thalamo-Cortical Network in Wilson’s Disease with Diffusion Tensor Imaging |
| title_full_unstemmed | Study on Lesion Assessment of Cerebello-Thalamo-Cortical Network in Wilson’s Disease with Diffusion Tensor Imaging |
| title_short | Study on Lesion Assessment of Cerebello-Thalamo-Cortical Network in Wilson’s Disease with Diffusion Tensor Imaging |
| title_sort | study on lesion assessment of cerebello thalamo cortical network in wilson s disease with diffusion tensor imaging |
| url | http://dx.doi.org/10.1155/2017/7323121 |
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