Tumour-derived exosomal miR-205 promotes ovarian cancer cell progression through M2 macrophage polarization via the PI3K/Akt/mTOR pathway

Tumour-derived exosomal miR-205 promotes ovarian cancer cell progression through M2 macrophage polarization via the PI3K/Akt/mTOR pathway

Abstract Background Tumour-associated macrophages (TAMs) are the most abundant immune cells in the tumour environment and are considered similar to M2 macrophages, which facilitate cancer progression. Exosomes, as important mediators of the cross-talk between tumour cells and tumour-associated macro...

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Bibliographic Details
Main Authors: Liuqing He, Quan Chen, Xiaoying Wu
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Journal of Ovarian Research
Subjects:
Exosomes
miR-205
Ovarian cancer
Macrophage polarization
PI3K/AKT/mTOR pathway
Online Access:https://doi.org/10.1186/s13048-025-01616-3
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https://doi.org/10.1186/s13048-025-01616-3

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