Analytical validation of the Percepta Nasal Swab classifier; an RNA next-generation sequencing assay for the assessment of lung cancer risk in pulmonary nodules

Analytical validation of the Percepta Nasal Swab classifier; an RNA next-generation sequencing assay for the assessment of lung cancer risk in pulmonary nodules

Abstract Background A novel molecular diagnostic test, Percepta Nasal Swab (PNS), was developed as a noninvasive lung cancer biomarker to aid in risk assessment for indeterminate pulmonary nodules in individuals who smoke or have previously smoked. Prior research has shown that exposure of the airwa...

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Bibliographic Details
Main Authors: Shuyang Wu, Ruochen Jiang, Grazyna Fedorowicz, Mei Wong, Janna S. Chamberlin, Lori Lofaro, P. Sean Walsh, Giulia C. Kennedy, Yangyang Hao, Jing Huang, Bill Bulman
Format: Article
Language:English
Published: BMC 2025-03-01
Series:BMC Cancer
Subjects:
Nasal Swab classifier
Analytical validation
Molecular diagnostic test
Lung cancer risk
Pulmonary nodules
Genomics
Online Access:https://doi.org/10.1186/s12885-025-13683-2
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