Prioritizing perturbation-responsive gene patterns using interpretable deep learning

Abstract Spatially resolved transcriptomics enables mapping of multiplexed gene expression within tissue contexts. While existing methods prioritize spatially variable genes within a single slice, few address identifying genes with differential spatial expression patterns (DSEPs) across multiple con...

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Bibliographic Details
Main Authors: Yan Cui, Zhiyuan Yuan
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61476-9
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