Personal model‐assisted identification of NAD+ and glutathione metabolism as intervention target in NAFLD

Personal model‐assisted identification of NAD+ and glutathione metabolism as intervention target in NAFLD

Abstract To elucidate the molecular mechanisms underlying non‐alcoholic fatty liver disease (NAFLD), we recruited 86 subjects with varying degrees of hepatic steatosis (HS). We obtained experimental data on lipoprotein fluxes and used these individual measurements as personalized constraints of a he...

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Main Authors: Adil Mardinoglu, Elias Bjornson, Cheng Zhang, Martina Klevstig, Sanni Söderlund, Marcus Ståhlman, Martin Adiels, Antti Hakkarainen, Nina Lundbom, Murat Kilicarslan, Björn M Hallström, Jesper Lundbom, Bruno Vergès, Peter Hugh R Barrett, Gerald F Watts, Mireille J Serlie, Jens Nielsen, Mathias Uhlén, Ulf Smith, Hanns‐Ulrich Marschall, Marja‐Riitta Taskinen, Jan Boren
Format: Article
Language:English
Published: Springer Nature 2017-03-01
Series:Molecular Systems Biology
Subjects:
glutathione
NAFLD
personalized genome‐scale metabolic modeling
serine
Online Access:https://doi.org/10.15252/msb.20167422
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https://doi.org/10.15252/msb.20167422

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