Cryo-EM structure and oligomerization of the human planar cell polarity core protein Vangl1

Abstract Vangl is a planar cell polarity (PCP) core protein essential for aligned cell orientation along the epithelial plane perpendicular to the apical-basal direction, which is important for tissue morphogenesis, development and collective cell behavior. Mutations in Vangl are associated with dev...

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Bibliographic Details
Main Authors: Fan Zhang, Shaobai Li, Hao Wu, Shanshuang Chen
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-55397-2
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