Propyl Gallate Exerts an Antimigration Effect on Temozolomide-Treated Malignant Glioma Cells through Inhibition of ROS and the NF-κB Pathway
In this study, we demonstrated that temozolomide (TMZ) and propyl gallate (PG) combination enhanced the inhibition of migration in human U87MG glioma cells. PG inhibited the TMZ-induced reactive oxygen species (ROS) generation. The mitochondrial complex III and NADPH oxidase are two critical sites t...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2017/9489383 |
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| _version_ | 1832568183259660288 |
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| author | Jen-Tsung Yang I-Neng Lee Fung-Jou Lu Chiu-Yen Chung Ming-Hsueh Lee Yu-Ching Cheng Kuo-Tai Chen Ching-Hsein Chen |
| author_facet | Jen-Tsung Yang I-Neng Lee Fung-Jou Lu Chiu-Yen Chung Ming-Hsueh Lee Yu-Ching Cheng Kuo-Tai Chen Ching-Hsein Chen |
| author_sort | Jen-Tsung Yang |
| collection | DOAJ |
| description | In this study, we demonstrated that temozolomide (TMZ) and propyl gallate (PG) combination enhanced the inhibition of migration in human U87MG glioma cells. PG inhibited the TMZ-induced reactive oxygen species (ROS) generation. The mitochondrial complex III and NADPH oxidase are two critical sites that can be considered to regulate antimigration in TMZ-treated U87MG cells. PG can enhance the antimigration effect of TMZ through suppression of metalloproteinase-2 and metalloproteinase-9 activities, ROS generation, and the NF-κB pathway and possibly provide a novel prospective strategy for treating malignant glioma. |
| format | Article |
| id | doaj-art-e41646a87456483f8efa7955c33289b4 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-e41646a87456483f8efa7955c33289b42025-02-03T00:59:38ZengWileyJournal of Immunology Research2314-88612314-71562017-01-01201710.1155/2017/94893839489383Propyl Gallate Exerts an Antimigration Effect on Temozolomide-Treated Malignant Glioma Cells through Inhibition of ROS and the NF-κB PathwayJen-Tsung Yang0I-Neng Lee1Fung-Jou Lu2Chiu-Yen Chung3Ming-Hsueh Lee4Yu-Ching Cheng5Kuo-Tai Chen6Ching-Hsein Chen7Department of Neurosurgery, Chang Gung Memorial Hospital, Chiayi 61363, TaiwanDepartment of Medical Research, Chang Gung Memorial Hospital, Chiayi 61363, TaiwanInstitute of Medicine, Chung Shan Medical University, Taichung, TaiwanDepartment of Neurosurgery, Chang Gung Memorial Hospital, Chiayi 61363, TaiwanDepartment of Neurosurgery, Chang Gung Memorial Hospital, Chiayi 61363, TaiwanDepartment of Neurosurgery, Chang Gung Memorial Hospital, Chiayi 61363, TaiwanDepartment of Neurosurgery, Chang Gung Memorial Hospital, Chiayi 61363, TaiwanDepartment of Microbiology, Immunology and Biopharmaceuticals, College of Life Sciences, National Chiayi University, Chiayi City 60004, TaiwanIn this study, we demonstrated that temozolomide (TMZ) and propyl gallate (PG) combination enhanced the inhibition of migration in human U87MG glioma cells. PG inhibited the TMZ-induced reactive oxygen species (ROS) generation. The mitochondrial complex III and NADPH oxidase are two critical sites that can be considered to regulate antimigration in TMZ-treated U87MG cells. PG can enhance the antimigration effect of TMZ through suppression of metalloproteinase-2 and metalloproteinase-9 activities, ROS generation, and the NF-κB pathway and possibly provide a novel prospective strategy for treating malignant glioma.http://dx.doi.org/10.1155/2017/9489383 |
| spellingShingle | Jen-Tsung Yang I-Neng Lee Fung-Jou Lu Chiu-Yen Chung Ming-Hsueh Lee Yu-Ching Cheng Kuo-Tai Chen Ching-Hsein Chen Propyl Gallate Exerts an Antimigration Effect on Temozolomide-Treated Malignant Glioma Cells through Inhibition of ROS and the NF-κB Pathway Journal of Immunology Research |
| title | Propyl Gallate Exerts an Antimigration Effect on Temozolomide-Treated Malignant Glioma Cells through Inhibition of ROS and the NF-κB Pathway |
| title_full | Propyl Gallate Exerts an Antimigration Effect on Temozolomide-Treated Malignant Glioma Cells through Inhibition of ROS and the NF-κB Pathway |
| title_fullStr | Propyl Gallate Exerts an Antimigration Effect on Temozolomide-Treated Malignant Glioma Cells through Inhibition of ROS and the NF-κB Pathway |
| title_full_unstemmed | Propyl Gallate Exerts an Antimigration Effect on Temozolomide-Treated Malignant Glioma Cells through Inhibition of ROS and the NF-κB Pathway |
| title_short | Propyl Gallate Exerts an Antimigration Effect on Temozolomide-Treated Malignant Glioma Cells through Inhibition of ROS and the NF-κB Pathway |
| title_sort | propyl gallate exerts an antimigration effect on temozolomide treated malignant glioma cells through inhibition of ros and the nf κb pathway |
| url | http://dx.doi.org/10.1155/2017/9489383 |
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