Advances in the Preparation of Fluorinated Isoquinolines: A Decade of Progress
Heterocyclic molecules incorporating fluorinated isoquinoline components are found in many medicinally and agriculturally important bioactive products as well as industrially impactful materials. Within the past decade, a variety of isoquinolinic ring assembly techniques has enabled the introduction...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2017/2860123 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832551985741561856 |
|---|---|
| author | Joseph C. Sloop |
| author_facet | Joseph C. Sloop |
| author_sort | Joseph C. Sloop |
| collection | DOAJ |
| description | Heterocyclic molecules incorporating fluorinated isoquinoline components are found in many medicinally and agriculturally important bioactive products as well as industrially impactful materials. Within the past decade, a variety of isoquinolinic ring assembly techniques has enabled the introduction of diverse fluorine-containing functionalities which can enhance potential bioactivity and industrial utility. This review examines recent noncatalyzed and transition metal catalyzed synthetic approaches to the assembly of isoquinoline derivatives that are ring-fluorinated and/or result in the incorporation of fluorine-containing functional groups. Specifically, efficient synthetic methods and regioselectivity in the incorporation of functional groups into isoquinoline ring systems are examined. |
| format | Article |
| id | doaj-art-e40b916e5a974e72b839d1d31a388ce8 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-e40b916e5a974e72b839d1d31a388ce82025-02-03T06:00:02ZengWileyJournal of Chemistry2090-90632090-90712017-01-01201710.1155/2017/28601232860123Advances in the Preparation of Fluorinated Isoquinolines: A Decade of ProgressJoseph C. Sloop0School of Science and Technology, Georgia Gwinnett College, 1000 University Center Lane, Lawrenceville, GA 30043, USAHeterocyclic molecules incorporating fluorinated isoquinoline components are found in many medicinally and agriculturally important bioactive products as well as industrially impactful materials. Within the past decade, a variety of isoquinolinic ring assembly techniques has enabled the introduction of diverse fluorine-containing functionalities which can enhance potential bioactivity and industrial utility. This review examines recent noncatalyzed and transition metal catalyzed synthetic approaches to the assembly of isoquinoline derivatives that are ring-fluorinated and/or result in the incorporation of fluorine-containing functional groups. Specifically, efficient synthetic methods and regioselectivity in the incorporation of functional groups into isoquinoline ring systems are examined.http://dx.doi.org/10.1155/2017/2860123 |
| spellingShingle | Joseph C. Sloop Advances in the Preparation of Fluorinated Isoquinolines: A Decade of Progress Journal of Chemistry |
| title | Advances in the Preparation of Fluorinated Isoquinolines: A Decade of Progress |
| title_full | Advances in the Preparation of Fluorinated Isoquinolines: A Decade of Progress |
| title_fullStr | Advances in the Preparation of Fluorinated Isoquinolines: A Decade of Progress |
| title_full_unstemmed | Advances in the Preparation of Fluorinated Isoquinolines: A Decade of Progress |
| title_short | Advances in the Preparation of Fluorinated Isoquinolines: A Decade of Progress |
| title_sort | advances in the preparation of fluorinated isoquinolines a decade of progress |
| url | http://dx.doi.org/10.1155/2017/2860123 |
| work_keys_str_mv | AT josephcsloop advancesinthepreparationoffluorinatedisoquinolinesadecadeofprogress |