scRNA seq of an F1 cross of Marek’s disease resistant and susceptible chickens identifies allele specific expression signatures enriched in transcription modulators

scRNA seq of an F1 cross of Marek’s disease resistant and susceptible chickens identifies allele specific expression signatures enriched in transcription modulators

Abstract Marek’s disease (MD), a T cell lymphoma disease in chickens, is caused by the Marek’s disease virus (MDV) found ubiquitously in the poultry industry. Genetically resistant Line 63 (L6) and susceptible Line 72 (L7) chickens have been instrumental to research on avian immune system response t...

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Bibliographic Details
Main Authors: Deborah Velez-Irizarry, Hans Cheng, Cari Hearn
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Marek’s Disease Virus
Single cell RNA sequencing
Allele specific expression
Genetic resistance
Avian immune response
Online Access:https://doi.org/10.1038/s41598-025-86174-w
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https://doi.org/10.1038/s41598-025-86174-w

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