Therapeutic management of PI3Kα inhibitor-induced hyperglycemia with a novel glucokinase activator: Advancing the Frontier of PI3Kα inhibitor therapy

Therapeutic management of PI3Kα inhibitor-induced hyperglycemia with a novel glucokinase activator: Advancing the Frontier of PI3Kα inhibitor therapy

Objectives: The phosphatidylinositol 3-kinase (PI3K) signaling pathway is a pivotal target in cancer treatment, driving substantial investigation into PI3K inhibitors (PI3Ki). However, the common on-target adverse effect of hyperglycemia presents a substantial challenge to their clinical application...

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Main Authors: Guanqin Jin, Shihuang Liu, Kewei Zheng, Xiaobo Cheng, Ranran Chai, Wei Ye, Wei Wei, Yongguo Li, Ai Huang, Guiling Li, Huan Yi, Yu Kang
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Molecular Metabolism
Subjects:
PI3K inhibitor (PI3Ki)
Hyperglycemia
Insulin signaling pathway
AKT/INSR/mTOR
Dorzagliatin
Blood glucose management
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877825000584
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