Difficult-to-Treat or Resistant Hypertension: Etiology, Pathophysiology, and Innovative Therapies

Despite the many therapeutic options available today for the treatment of hypertension, a sizable number of patients still remain resistant to treatment. The prevalence of resistant hypertension in the general population under optimal conditions is about 3–5%. Although several factors and conditions...

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Main Authors: Vasilios Papademetriou, Costas Tsioufis, Alan Gradman, Henry Punzi
Format: Article
Language:English
Published: Wiley 2011-01-01
Series:International Journal of Hypertension
Online Access:http://dx.doi.org/10.4061/2011/438198
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author Vasilios Papademetriou
Costas Tsioufis
Alan Gradman
Henry Punzi
author_facet Vasilios Papademetriou
Costas Tsioufis
Alan Gradman
Henry Punzi
author_sort Vasilios Papademetriou
collection DOAJ
description Despite the many therapeutic options available today for the treatment of hypertension, a sizable number of patients still remain resistant to treatment. The prevalence of resistant hypertension in the general population under optimal conditions is about 3–5%. Although several factors and conditions can be identified and corrected a percentage of hypertensive patients remain with unacceptably high blood pressure levels. The high prevalence of hypertension in the general population renders this small percentage significant, in terms of actual patient numbers. This special issue of the journal expoars a whole spectrum of topics related to resistant hypertension: several articles address pathophysiolog and secondary causes of resistant hypertension and modern approaches to therapy. Of interest is the referance to the newer interventional approaches, that is, Baroreceptor stimulation therapy and catheter based sympathetic renal denervation.
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series International Journal of Hypertension
spelling doaj-art-e3c33f38d9dc4bc6befbf29b2047fa0f2025-02-03T01:10:31ZengWileyInternational Journal of Hypertension2090-03922011-01-01201110.4061/2011/438198438198Difficult-to-Treat or Resistant Hypertension: Etiology, Pathophysiology, and Innovative TherapiesVasilios Papademetriou0Costas Tsioufis1Alan Gradman2Henry Punzi3Cardiovascular Research, VA Medical Center, 50 Irving Street NW, Washington, DC 20422, USAFirst Cardiology Clinic, Hippokration Hospital, University of Athens, 114 Vassilissis Sofias Avenue, Athens 11527, GreeceDivision of Cardiology, Temple University School of Medicine; Clinical Campus, Pittsburgh, PA 15232, USATrinity Hypertension Research Institute and Metabolic Research Institute, Punzi Medical Center, Carrollton, TX 75006, USADespite the many therapeutic options available today for the treatment of hypertension, a sizable number of patients still remain resistant to treatment. The prevalence of resistant hypertension in the general population under optimal conditions is about 3–5%. Although several factors and conditions can be identified and corrected a percentage of hypertensive patients remain with unacceptably high blood pressure levels. The high prevalence of hypertension in the general population renders this small percentage significant, in terms of actual patient numbers. This special issue of the journal expoars a whole spectrum of topics related to resistant hypertension: several articles address pathophysiolog and secondary causes of resistant hypertension and modern approaches to therapy. Of interest is the referance to the newer interventional approaches, that is, Baroreceptor stimulation therapy and catheter based sympathetic renal denervation.http://dx.doi.org/10.4061/2011/438198
spellingShingle Vasilios Papademetriou
Costas Tsioufis
Alan Gradman
Henry Punzi
Difficult-to-Treat or Resistant Hypertension: Etiology, Pathophysiology, and Innovative Therapies
International Journal of Hypertension
title Difficult-to-Treat or Resistant Hypertension: Etiology, Pathophysiology, and Innovative Therapies
title_full Difficult-to-Treat or Resistant Hypertension: Etiology, Pathophysiology, and Innovative Therapies
title_fullStr Difficult-to-Treat or Resistant Hypertension: Etiology, Pathophysiology, and Innovative Therapies
title_full_unstemmed Difficult-to-Treat or Resistant Hypertension: Etiology, Pathophysiology, and Innovative Therapies
title_short Difficult-to-Treat or Resistant Hypertension: Etiology, Pathophysiology, and Innovative Therapies
title_sort difficult to treat or resistant hypertension etiology pathophysiology and innovative therapies
url http://dx.doi.org/10.4061/2011/438198
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AT costastsioufis difficulttotreatorresistanthypertensionetiologypathophysiologyandinnovativetherapies
AT alangradman difficulttotreatorresistanthypertensionetiologypathophysiologyandinnovativetherapies
AT henrypunzi difficulttotreatorresistanthypertensionetiologypathophysiologyandinnovativetherapies