Regulating Sirtuin 3-mediated mitochondrial dynamics through vanillic acid improves muscle atrophy in cancer-induced cachexia

Regulating Sirtuin 3-mediated mitochondrial dynamics through vanillic acid improves muscle atrophy in cancer-induced cachexia

Abstract Cancer cachexia is a cancer-associated disease characterized by gradual body weight loss due to pathologic muscle and fat loss, but effective treatments are still lacking. Here, we investigate the possible effect of vanillic acid (VA), known for its antioxidant, anti-inflammatory, and anti-...

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Main Authors: Gahee Song, Jinbong Park, Yunu Jung, Woo Yong Park, Ja Yeon Park, Se Jin Jung, Beomsu Kim, Minji Choi, Sang Hee Kim, Seong-Kyu Choe, Hyun Jeong Kwak, Junhee Lee, Kil Yeon Lee, Kwang Seok Ahn, Jae-Young Um
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-07770-0
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https://doi.org/10.1038/s42003-025-07770-0

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