Pathway-based cancer transcriptome deciphers a high-resolution intrinsic heterogeneity within bladder cancer classification

Pathway-based cancer transcriptome deciphers a high-resolution intrinsic heterogeneity within bladder cancer classification

Abstract Background The heterogeneity of bladder cancer (BLCA) is affected by its inherent transcriptional properties and tumor microenvironment (TME). Stromal transcriptional components in the TME significantly influence the transcriptional classification of BLCA, and the intrinsic biological trans...

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Bibliographic Details
Main Authors: Zhan Wang, Zhaokai Zhou, Shuai Yang, Zhengrui Li, Run Shi, Ruizhi Wang, Kui Liu, Xiaojuan Tang, Qi Li
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Journal of Translational Medicine
Subjects:
Bladder cancer
Single-cell RNA-seq
Intrinsic heterogeneity
Molecular subtypes
Metabolic disorder
Immune microenvironment
Online Access:https://doi.org/10.1186/s12967-025-06682-1
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https://doi.org/10.1186/s12967-025-06682-1

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