The N-terminal PA domains of signal-peptide-peptidase-like 2 (SPPL2) proteases impact on TNFα cleavage

The N-terminal PA domains of signal-peptide-peptidase-like 2 (SPPL2) proteases impact on TNFα cleavage

Abstract Signal peptide peptidase-like (SPPL) proteases, members of the intramembrane aspartyl protease family, have attracted increased interest due to their involvement in immune cell differentiation and cellular glycan structure regulation. However, the enzymatic domain involved in substrate reco...

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Main Authors: Christine Schlosser, Kinda Sharrouf, Alkmini A. Papadopoulou, Martina Haug-Kröper, Suman Singh, Maximilian Johler, Jonas Pettinger, Henrike Horn, Marco Koch, Sabine Hoeppner, Regina Fluhrer
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08102-y
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https://doi.org/10.1038/s42003-025-08102-y

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